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Chemistry

Analytical chemistry

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  • Published Date
Displaying 101 - 125 of 2084

Engineering Nanopore Approaches toward Protein Sequencing

July 25, 2023
Author(s)
Xiaojun Wei, Tadas Penkauskas, Joseph Reiner, Mark Uline, Qian Wang, Sheng Li, Aleksei Aksimentiev, Joseph Robertson, Chang Liu
Biotechnological innovations have vastly improved the capacity to perform large-scale protein studies, while the methods we have of identifying and quantifying individual proteins are still inadequate to perform protein sequencing at the single-molecule

On the challenge of unambiguous identification of fentanyl analogs: exploring measurement diversity using standard reference mass spectral libraries

July 11, 2023
Author(s)
Arun Moorthy, Edward Erisman, Anthony J. Kearsley, Yuxue Liang, Edward Sisco, William E. Wallace
Fentanyl analogs are a class of designer drugs that are particularly challenging to unambiguously identify due to the mass spectral and retention time similarities of unique compounds. In this paper, we use agglomerative hierarchical clustering to explore

Use of non-targeted and suspect screening analysis to detect sources of human exposure to environmental contaminants

June 28, 2023
Author(s)
Katherine Manz, Anna Feerick, Joseph Braun, Yong-Lai Feng, Amber Hall, Jeremy Koelmel, Carlos A. Manzano, Seth Newton, Kurt Pennell, Benjamin Place, Krystal Godri Pollitt, Carsten Prasse, Joshua Young
Non-targeted analysis (NTA) and suspect screening analysis (SSA) are powerful techniques that rely on high-resolution mass spectrometry (HRMS) and computational tools to detect and identify unknown or suspected compounds in environmental media and human

Direct Visualization of Chemically Resolved Multilayered Domains in Mixed-Linker Metal-Organic Frameworks

June 15, 2023
Author(s)
Andrea Centrone, Belen Lerma-Berlanga, Adam Biacchi, Carmen Fernandez Conde, Georges Pavlidis, Carlos Marti-Gastaldo
The modular synthesis approach for assembling inorganic nodes and organic multidentate linkers into reticular solids enables rational engineering in porous materials known as metal-organic frameworks (MOFs). Incorporation of two or more linker types in MOF

Food Nutrition and Safety Measurements Quality Assurance Program: Exercise 1 Final Report

May 18, 2023
Author(s)
Colleen E. Bryan Sallee, Melissa M. Phillips, Charles Barber, Carolyn Burdette, Laura Wood, Shaun Kotoski
The Food Nutrition and Safety Measurements Quality Assurance Program (FNSQAP) was launched in 2021. FNSQAP was established to assist laboratories in the development and validation of new analytical methods, in improving the quality of their analytical

Determination of 24,25-dihydroxyvitamin D3 in Vitamin D External Quality Assessment Scheme samples using a reference measurement procedure

May 9, 2023
Author(s)
Stephen Wise, Grace Hahm, Carolyn Burdette, Susan Tai, Johanna Camara, Adam Kuszak, Emma Williams
Ninety archived human serum samples from the Vitamin D External Quality Assessment Scheme (DEQAS) were analyzed using a reference measurement procedure (RMP) based on isotope dilution liquid chromatography - tandem mass spectrometry (ID LC-MS/MS) for the

Per- and Polyfluoroalkyl Substances in New Firefighter Turnout Gear Textiles

May 1, 2023
Author(s)
Andrew Maizel, Andre Thompson, Meghanne Tighe, Samuel Escobar Veras, Alix Rodowa, Ryan Falkenstein-Smith, Bruce A. Benner Jr., Kathleen Hoffman, Michelle K. Donnelly, Olivia Hernandez, Nadine Wetzler, Trung Ngu, Jessica Reiner, Benjamin Place, John Kucklick, Kate Rimmer, Rick D. Davis
Turnout gear is increasingly recognized as a potential source of per- and polyfluoroalkyl substance (PFAS) exposure to firefighters. To determine the type, concentration, and prevalence of PFAS potentially present in new firefighter turnout gear, fifty

Size-exclusion chromatography

April 20, 2023
Author(s)
Andre Striegel
Over the past half-century, size-exclusion chromatography (SEC) has become the premier method by which to determine the molar mass (M) averages and the molar mass distribution (MMD) of natural and synthetic macromolecules. When coupled to a multiplicity of

Humanized Monoclonal Antibody IgG1k, NISTmAb RM 8671 Summary of 5 Year Stability Verification (5YSV)

March 31, 2023
Author(s)
Katharina Yandrofski, John E. Schiel, Trina Mouchahoir, Srivalli Telikepalli, N. Alan Heckert, Dean C. Ripple, Paul C. DeRose, Karen W. Phinney, John Marino
NISTmAb RM 8671 is an IgG1κ monoclonal antibody that has been extensively characterized and released as the first of its kind biopharmaceutical reference material in 2016. This material was intended primarily for use in evaluating the performance of

Food Nutrition and Safety Measurements Quality Assurance Program: Exercise 1 Final Report

March 22, 2023
Author(s)
Colleen E. Bryan Sallee, Melissa M. Phillips, Charles Barber, Carolyn Burdette, Shaun Kotoski, Laura Wood
The Food Nutrition and Safety Measurements Quality Assurance Program (FNSQAP) was launched in 2021. FNSQAP was established to assist laboratories in the development and validation of new analytical methods, in improving the quality of their analytical

Green sea turtles (Chelonia mydas) accumulate heavy metals near a former skeet shooting range in Kailua, O'ahu, Hawai'i

March 3, 2023
Author(s)
Katherine Shaw, George Balazs, T. Todd Jones, Harry Lynch, Jing Liu, George Cobb, David Klein, Jennifer Lynch
This study determined if green sea turtles (Chelonia mydas) in Kailua Bay, Oahu, in the Hawaiian Islands have elevated blood and scute Pb, As, and Sb concentrations resulting from lead deposition at a historic skeet shooting range. Blood and scute samples

Certification of Standard Reference Material(R) 917d D Glucose (Dextrose)

March 1, 2023
Author(s)
Michael Nelson, Brian Lang, Blaza Toman, Jerome Mulloor
Standard Reference Material (SRM) 917d D Glucose (Dextrose) is certified as a chemical substance of known high purity. It is intended for use in calibrating measuring systems for glucose determinations employed in clinical analysis. A unit of SRM 917d

Characterization of Reference Materials 8690 to 8693

February 13, 2023
Author(s)
Jessica Reiner, Benjamin Place, N. Alan Heckert, Katherine Peter, Alix Rodowa
The National Institute of Standards and Technology (NIST) Reference Materials (RMs) 8690 Per- and Polyfluoroalkyl Substances (PFAS) in Aqueous Film-Forming Foams (AFFF) Formulation I, RM 8691 Per- and Polyfluoroalkyl Substances (PFAS) in Aqueous Film

Methods for the SI Value Assignment of the Purity of Organic Compounds (IUPAC Technical Report)

January 18, 2023
Author(s)
David Duewer, Katrice Lippa, Brian Lang, Blaza Toman, Michael Nelson, Kenneth W. Pratt, Steven Westwood, Yoshitaka Yoshitaka Shimuzu, Takeshi Saito, Beatrice Lalerle, Xinhua Dai, Stephen Davies, Marina Ricci, Annarita Baldan, Stefan Sarge, Haifeng Wang, Ralf D. Josephs, Michal Mariassy, Dietmar Pfieffer, John Warren, Wolfram Bremser, Stephen L.R. Ellison, Ting Huang, Ales Fajgelj, Lindsey Mackay, Robert Wielgosz
Metrological traceability to the SI of the result of an analysis for an organic compound is achieved through a calibration hierarchy anchored in a primary calibrator of the compound, the mass fraction content of which is established in a manner traceable

Value Assignment of Standard Reference Material(R) 1849b Infant/Adult Nutritional Formula I

January 6, 2023
Author(s)
Melissa M. Phillips, Laura Wood, Charles Barber, Bruce Scruggs, John Sieber, James H. Yen, Lee L. Yu
The National Institute of Standards and Technology (NIST) Standard Reference Material® (SRM®) 1849b Infant/Adult Nutritional Formula I delivers certified or non-certified values for over 100 analytes. This material is intended to be used for the evaluation

Field-Deployable Devices

January 1, 2023
Author(s)
Thomas P. Forbes, Raychelle Burks
Reductions in instrument size, weight, and power continue to facilitate the development and application of field-deployable devices for investigative purposes. Portable analytical instrumentation supporting the rapid and reliable identification of two

Isotope Dilution Mass Spectrometry as an Independent Assessment for Mass Measurements of Milligram Quantities of Aqueous Solution

January 1, 2023
Author(s)
Richard Essex, Jacqueline L. Mann, Denis E. Bergeron, Ryan P. Fitzgerald, Svetlana Nour, Gordon A. Shaw, R. Michael Verkouteren
Isotope dilution mass spectrometry was used to independently assess the accuracy of mass measurement methods developed to quantitatively dispense milligram quantities of aqueous solution. Solutions of isotopically enriched 158Gd and enriched 155Gd were
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