Modeling of Photochemical Reactions in a Focused Laser Beam

Published

July 1, 2007

Author(s)

Fern Y. Hunt, Adolfas Gaigalas, Lili Wang

Abstract

This paper presents a mathematical model of photodegradation of fluorophores passing through a laser beam. The beam is focused on the sample and thus the power distribution of incident light is strongly dependent on spatial location while the fluorophores are subject to a convective fluid flow. Experimentally accessible equations describing the time evolution of the fluorescent response over the entire region are derived. Mathematical justification for them is based on a multiple time scale analysis of the kinetics and approximations based on the amplitude of oscillatory component of the laser beam. The resulting equations can be used to interpret frequency domain measurements using traditional impedance concepts.

Citation

Journal of Research (NIST JRES) -

Volume

112

Issue

4

NIST Pub Series

Journal of Research (NIST JRES)

Pub Type

NIST Pubs

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Keywords

flowing solution, frequency domain, mathematical modeling, modulated laser illumination, photodegradation, singular perturbation technique

Citation

Hunt, F. , Gaigalas, A. and Wang, L. (2007), Modeling of Photochemical Reactions in a Focused Laser Beam, Journal of Research (NIST JRES), National Institute of Standards and Technology, Gaithersburg, MD, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=50915 (Accessed October 20, 2025)