Optimization of magnetic nanoparticle synthesis for a specific biomedical application necessitates a solid understanding of both the fundamental magnetism and its measurement. Since most pharmaceutical companies employ biologists and chemists without such knowledge, we will aim to develop an ASTM standard for their use, applying established bulk and thin film techniques to nanoparticles systems for determining the appropriate magnetic properties of both individual and collections of nanoparticles.
In addition, two new measurement techniques will be developed: First Order Reversal Curve (FORC) models to correlate physical size distributions with magnetic property distributions and transverse AC Susceptometry for determining interaction timescale for individual and collective systems.
There are also specific requirements for each medical application. For example, a novel variable field and frequency relaxometer will be developed for correlating the materials structure with T1 and T2 times to develop stable T1 and T2 SRMs for quantitative MRIs. For hyperthermia therapy, a micro-calorimeter will be developed for accurately measuring temperature changes in a nanoparticle suspension under the influence of a high frequency alternating magnetic field.