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Zachary Goecker (Fed)

NRC Postdoctoral Fellow

Dr. Goecker works on solving problems in mass spectrometry and proteomics, primarily within the fields of virology and forensic science. His research interests include site-specific glycosylation, forensic serology, forensic proteomics, low-template DNA quantification, and natural products research. Dr. Goecker completed his PhD work at UC Davis under the supervision of Robert Rice and Glendon Parker, where he worked on establishing methods in human identification and ancestral classification from genetic variants within human hair shaft proteins. His current work within the Mass Spectrometry Data Center group involves the evaluation of glycosylation patters on influenza glycoproteins from vaccines and recombinant sources as a means to improve QC measures in biomanufacturing. 


Poster Presentations

06/2022

“Variation of Site-Specific Glycosylation Profiles for Influenza Glycoproteins from Recombinant Sources and Vaccines” Presented at the American Society for Mass Spectrometry (Download)

11/2021

“Site-Specific Glycosylation Profiles for Recombinant Hemagglutinin and Neuraminidase from Different Sources” Presented at the American Society for Mass Spectrometry (Download)


Oral Presentations

03/2023

“Variation of Site-Specific Glycosylation Profiles for Influenza Glycoproteins from Different Vaccines and Recombinant Sources” Presented at the Pittcon Conference and Exhibition. (Download)

02/2023

“Developing Reproducible Methods in Site-Specific Glycosylation Analysis” Presented at the Washington Baltimore Mass Spectrometry Discussion Group (Download)

01/2023

“Measuring Variation in Glycosylation Among Influenza Vaccine Glycoproteins” Presented at NIST Biomolecular Measurement Division Seminar (Download)

05/2022

“Variation of Site-Specific Glycosylation Profiles for Influenza Glycoproteins from Different Sources” Presented at NIST Biomolecular Measurement Division Seminar (Download)


Coauthor Presentations

06/2022

“Proteases Used For Measurement Of Site-Specific Distributions Of N-Linked Glycans In Multiple Full Length RecombinantSARS-CoV-2 Spike Proteins” – Presenting Author Yi Liu (Poster) at the American Society for Mass Spectrometry

 

Publications

Comparison of N-glycopeptide to released N-glycan abundances and the influence of glycopeptide mass and charge state on N-linked glycosylation of IgG antibodies

Author(s)
Concepcion Remoroza, Meghan Burke Harris, Tytus Mak, Sergey Sheetlin, Yuri Mirokhin, Zachary Goecker, Brian T. Cooper, Mark Lowenthal, Xiaoyu (Sara) Yang, Guanghui Wang, Dmitrii V. Tchekhovskoi, Stephen E. Stein
We report the comparison of mass-spectral-based abundances of tryptic glycopeptides to fluorescence abundances of released labeled glycans and the effects of
Created April 14, 2021, Updated May 2, 2023