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Sheng Lin-Gibson

Dr. Sheng Lin-Gibson is the Chief of the Biosystems and Biomaterials Division (BBD) at the National Institute of Standards and Technology (NIST).  BBD has a multidisciplinary technical portfolio that includes genomic measurements, synthetic biology, regenerative medicine and advanced therapies, biomaterials, diagnostics, and complex microbial systems. BBD carries out its mission through fundamental research in measurement science, the development of new technologies, and the deployment of new measurement solutions, including reference materials and data.
More information about BBD:
Honors and Awards:
Department of Commerce (DoC) Bronze Medal: Cell Counting Measurements (2017)
Department of Commerce (DoC) Bronze Medal: Metrology for Dental Materials (2014)
NIST Sigma Xi Young Investigator Award (2011)
National Academy of Engineering (NAE) China-America Frontiers of Engineering (2011)
Department of Commerce (DoC) Bronze Medal: Combinatorial Testing of Biomaterials (2010)
NIST/NRC Postdoctoral Research Fellowship




  • Chen C, Weir MD, Cheng L, Lin NJ, Lin-Gibson S, Chow LC, Zhou XD, Xu HHK, Antibacterial Activity and Ion Release of Bonding Agent Containing Amorphous Calcium Phosphate Nanoparticles, Dental Materials, 2014, 30(8), 891-901.

  • Wang DB, Ye J, Hudson SD, Scott, KCK, Lin-Gibson S. Effect of Nanoparticles Size and Charge on Interactions with Self-Assembled Collagen. Journal of Colloid and Interface Science, 2014, 417, 244-249. 

  • Waters MS, Kindu S, Lin NJ, Lin-Gibson S, Microstructure and Mechanical Properties of in Situ Streptococcus mutans Biofilms, ACS Applied Materials & Interfaces, 2014, 6(1), 327-332. 

  • Ye J, Wang DB, Zeiger DN, Miles WC, Lin-Gibson S. Different Kinetic Pathways of Early Stage Calcium-Phosphate Cluster Aggregation Induced by Carboxylate-Containing Polymers, Biomacromolecules, 2013, 14(13), 3417-3422. 

  • Zhang K, Cheng L, Imazato S, Antonucci JM, Lin NJ, Lin-Gibson S, Bai YX, Xu HHK. Effects of Dual Antibacterial Agents MDPB and Nano-silver in Primer on Microcosm Biofilm, Cytotoxicity and Dentine Bond Properties. Journal of Dentistry, 2013, 41(5), 464-474.

  • Tutak W, Sarkar S, Lin-Gibson S, Farooque TM, Jyotsnendu G, Wang D, Kohn J, Bolikal D, Simon CG, The Support of Bone Marrow Stromal Cell Differentiation by Airbrushed Nanofiber Scaffold, Biomaterials, 2013, 34(10), 2389-2398. 

  • Kraigsley AM, Tang K, Lippa KA, Howarter JA, Lin-Gibson S, Lin NJ. Effect of Polymer Degree of Conversion on Streptococcus mutans Biofilms. Macromolecular Biosciences, 2012, 12(12), 1706-1713. 

  • Cheng L, Weir MD, Xu HHK, Antonucci JM, Lin NJ, Lin-Gibson S, Xu SM, Zhou XD. Effect of Amorphous Calcium Phosphate and Silver Nanocomposites on Dental Plaque Microcosm Biofilms, J Biomed Mater Res B, 2012, 100B(5), 1378-1386. 

  • Cheng L, Weir MD, Xu HHK, Kraigsley AM, Lin NJ, Lin-Gibson S, Zhou X. Antibacterial and physical properties of calcium-phosphate and calcium-fluoride nanocomposites with chlorhexidine. Dental Materials, 2012, in press. 

  • Cheng L, Weir MD, Xu HHK, Antonucci JM, Kraigsley AM, Lin NJ, Lin-Gibson S, Zhou X. Antibacterial amorphous calcium phosphate nanocomposites with a quaternary ammonium dimethacrylate and silver nanoparticles. Dental Materials, 2012, accepted.

  • Lin NJ, Antonucci JM, Zeiger DN, Tang K, Lin-Gibson S. Positively-charged dimethacrylates to reduce bacterial attachment. Biomaterials Forum, 2012, in press.

  • Wear, K.A., Nagaraja, S., Dreher, M.L., Lin-Gibson, S. Relationship of quantitative ultrasound parameters with cancellous bone microstructure in human calcaneus in vitro, Journal of the Acoustical Society of America, 2012, in press.

  • Antonucci JM, Zeiger DN, Tang K, Lin-Gibson S, Fowler BO, Lin NJ. Synthesis and characterization of dimethacrylates containing quaternary ammonium functionalities for dental applications. Dental Materials, 2012, 28(2): 219-228.

  • Lin, N.J.; Lin-Gibson, S.; Sun, J.; Ding, Y. Effects of Polymeric Nanogratings on Cell Orientation, Biomaterials Forum, 2011

  • Chiang M.Y.M.; Giuseppetti, A.M.; Qian J.; Dunkers J.P.; Antonucci J.M.; Schumacher, G.E.; Lin- Gibson, S. Analyses of a Cantilever-Beam Based Instrument for Evaluating the Development of Polymerization Stresses, Dental Materials, 2011, 27, 899-905.

  • Zeiger, Diana N.; Miles, William C.; Eidelman, Naomi; Lin-Gibson, Sheng, Cooperative Calcium Phosphate Nucleation within Collagen Fibrils, Langmuir, 2011, 27, 8262-8268.

  • Parekh, Sapun H.; Chatterjee, Kaushik; Lin-Gibson, Sheng; Moore, Nicole M.; Cicerone, Marcus T.; Young, Marian F.; Simon, Carl G., Jr.  Modulus-driven differentiation of marrow stromal cells in 3D scaffolds that is independent of myosin-based cytoskeletal tension, Biomaterials, 2011, 32, 2256-2264.

  • Cheng, Y.J.; Zeiger, D.N.; Howarter, J.; Zhang, X.; Lin, N.J.; Antonucci, J.M.; Lin-Gibson, S. In situ Formation of Silver Nanoparticles in Photo-cross-linking Polymers. Journal of Biomedical Materials Research: Part B, 2011, 97B, 124-131.

  • Simon, Jr. C.G.; Lin-Gibson, S. Combinatorial and High-Throughput Screening of Biomaterials. Advanced Materials 2011, 23, 369-387.

  • Cheng, Y. J.; Antonucci, J. M.; Hudson, S. D.; Lin, N. J.; Zhang, X. R.; Lin-Gibson, S. Controlled In Situ Nanocavitation in Polymeric Materials. Advanced Materials 2011, 23, 409-413.

  • Ding, Y. F.; Sun, J. R.; Ro, H. W.; Wang, Z.; Zhou, J.; Lin, N. J.; Cicerone, M. T.; Soles, C. L.; Lin-Gibson, S. Thermodynamic Underpinnings of Cell Alignment on Controlled Topographies. Advanced Materials 2011, 23, 421-425.

  • Zeiger, D. N.; Stafford, C. M.; Cheng, Y. J.; Leigh, S. D.; Lin-Gibson, S.; Lin, N. J. Effects of Sample Preparation on Bacterial Colonization of Polymers. Langmuir 2010, 26, 2659-2664.

  • Chatterjee, K.; Lin-Gibson, S.; Wallace, W. E.; Parekh, S. H.; Lee, Y. J.; Cicerone, M. T.; Young, M. F.; Simon, C. G. The Effect of 3D Hydrogel Scaffold Modulus on Osteoblast Differentiation and Mineralization Revealed by Combinatorial Screening. Biomaterials 2010, 31, 5051-5062.

  • Ding, Y. F.; Qi, H. J.; Alvine, K. J.; Ro, H. W.; Ahn, D. U.; Lin-Gibson, S.; Douglas, J. F.; Soles, C. L. Stability and Surface Topography Evolution in Nanoimprinted Polymer Patterns Under a Thermal Gradient. Macromolecules 2010, 43, 8191-8201.

  • Sun, J. R.; Ding, Y. F.; Lin, N. J.; Zhou, J.; Ro, H.; Soles, C. L.; Cicerone, M. T.; Lin-Gibson, S. Exploring Cellular Contact Guidance Using Gradient Nanogratings. Biomacromolecules 2010, 11, 3067-3072.

  • Sun, J.; Eidelman, N.; Lin-Gibson, S. 3D Mapping of Polymerization Shrinkage Using X-Ray Micro-Computed Tomography to Predict Microleakage. Dental Materials 2009, 25, 314-320.

  • Grieshaber, S. E.; Farran, A. J. E.; Lin-Gibson, S.; Kiick, K. L.; Jia, X. Q. Synthesis and Characterization of Elastin-Mimetic Hybrid Polymers With Multiblock, Alternating Molecular Architecture and Elastomeric Properties. Macromolecules 2009, 42, 2532-2541.

  • Dorsey, S. M.; Lin-Gibson, S.; Simon, C. G. X-Ray Microcomputed Tomography for the Measurement of Cell Adhesion and Proliferation in Polymer Scaffolds. Biomaterials 2009, 30, 2967-2974.

  • Lin-Gibson, S.; Sung, L. P.; Forster, A. M.; Hu, H. Q.; Cheng, Y. J.; Lin, N. J. Effects of Filler Type and Content on Mechanical Properties of Photopolymerizable Composites Measured Across Two-Dimensional Combinatorial Arrays. Acta Biomaterialia 2009, 5, 2084-2094.

  • Lin, N. J.; Hu, H. Q.; Sung, L. P.; Lin-Gibson, S. Quantification of Cell Response to Polymeric Composites Using a Two-Dimensional Gradient Platform. Combinatorial Chemistry & High Throughput Screening 2009, 12, 619-625.

  • Alvine, K.J.; Ding Y.F.; Douglas J.F.; Ro H.W.; Okerberg B.C.; Karim A; Lavery K.A.; Lin-Gibson S.; Soles C.L. Effect of Fluorosurfactant on Capillary Instability in Nanoimprinted Polymer Patterns. Journal of Polymer Science Part B- Polymer Physics 2009, 47, 2591-2600.

  • Lin, N. J.; Lin-Gibson, S. Osteoblast Response to Dimethacrylate Composites Varying in Composition, Conversion and Roughness Using a Combinatorial Approach. Biomaterials 2009, 30, 4480-4487.

  • Zeiger, D. N.; Sun, J. R.; Schumacher, G. E.; Lin-Gibson, S. Evaluation of Dental Composite Shrinkage and Leakage in Extracted Teeth Using X-Ray Microcomputed Tomography. Dental Materials 2009, 25, 1213-1220.

  • Jirun, S.; Rui, F.; Lin, N.; Eidelman, N.; Lin-Gibson, S. Nondestructive Quantification of Leakage at the Tooth-Composite Interface and Its Correlation With Material Performance Parameters. Biomaterials 2009, 4457-4462.

  • Sun, J. R.; Lin-Gibson, S. X-Ray Microcomputed Tomography for Measuring Polymerization Shrinkage of Polymeric Dental Composites. Dental Materials 2008, 24, 228-234.

  • Yang, Y. Y.; Dorsey, S. M.; Becker, M. L.; Lin-Gibson, S.; Schumacher, G. E.; Flaim, G. A.; Kohn, J. C.; Simon, C. G. X-Ray Imaging Optimization of 3D Tissue Engineering Scaffolds Via Combinatorial Fabrication Methods. Biomaterials 2008, 29, 1901-1911.

  • Hobbie, E. K.; Lin-Gibson, S.; Kumar, S. Non-Brownian Microrheology of a Fluid-Gel Interface. Physical Review Letters 2008, 100.

  • Morgan, A. W.; Roskov, K. E.; Lin-Gibson, S.; Kaplan, D. L.; Becker, M. L.; Simon, C. G. Characterization and Optimization of RGD-Containing Silk Blends to Support Osteoblastic Differentiation. Biomaterials 2008, 29, 2556-2563.

  • Madsen, E. L.; Frank, G. R.; Hobson, M. A.; Lin-Gibson, S.; Hall, T. J.; Jiang, J.; Stiles, T. A. Instrument for Determining the Complex Shear Modulus of Soft-Tissue-Like Materials From 10 to 300 Hz. Physics in Medicine and Biology 2008, 53, 5313-5342.

  • Cooper, J. A.; Li, W. J.; Bailey, L. O.; Hudson, S. D.; Lin-Gibson, S.; Anseth, K. S.; Tuan, R. S.; Washburn, N. R. Encapsulated Chondrocyte Response in a Pulsatile Flow Bioreactor. Acta Biomaterialia 2007, 3, 13-21.

  • Kashiwagi, T.; Fagan, J.; Douglas, J. F.; Yamamoto, K.; Heckert, A. N.; Leigh, S. D.; Obrzut, J.; Du, F. M.; Lin-Gibson, S.; Mu, M. F.; Winey, K. I.; Haggenmueller, R. Relationship Between Dispersion Metric and Properties of PMMA/SWNT Nanocomposites. Polymer 2007, 48, 4855-4866.

  • Lin, N. J.; Drzal, P. L.; Lin-Gibson, S. Two-Dimensional Gradient Platforms for Rapid Assessment of Dental Polymers: A Chemical, Mechanical and Biological Evaluation. Dental Materials 2007, 23, 1211-1220.

  • Lin-Gibson, S.; Cooper, J. A.; Landis, F. A.; Cicerone, M. T. Systematic Investigation of Porogen Size and Content on Scaffold Morphometric Parameters and Properties. Biomacromolecules 2007, 8, 1511-1518.

  • Landis, F. A.; Stephens, J. S.; Cooper, J. A.; Cicerone, M. T.; Lin-Gibson, S. Tissue Engineering Scaffolds Based on Photocured Dimethacrylate Polymers for in Vitro Optical Imaging. Biomacromolecules 2006, 7, 1751-1757.

  • Lin-Gibson, S.; Landis, F. A.; Drzal, P. L. Combinatorial Investigation of the Structure-Properties Characterization of Photopolymerized Dimethacrylate Networks. Biomaterials 2006, 27, 1711-1717.

  • Wilder, E. A.; Guo, S.; Lin-Gibson, S.; Fasolka, M. J.; Stafford, C. M. Measuring the Modulus of Soft Polymer Networks Via a Buckling-Based Metrology. Macromolecules 2006, 39, 4138-4143.

  • Byrd, H. C. M.; Bencherif, S. A.; Bauer, B. J.; Beers, K. L.; Brun, Y.; Lin-Gibson, S.; Sari, N. Examination of the Covalent Cationization Method Using Narrow Polydisperse Polystyrene. Macromolecules 2005, 38, 1564-1572.

  • Dundigalla, A.; Lin-Gibson, S.; Ferreiro, V.; Malwitz, M. M.; Schmidt, G. Unusual Multilayered Structures in Poly(Ethylene Oxide)/Laponite Nanocomposite Films. Macromolecular Rapid Communications 2005, 26, 143-149.

  • Patel, N. P.; Hunt, M. A.; Lin-Gibson, S.; Bencherif, S.; Spontak, R. J. Tunable CO2 Transport Through Mixed Polyether Membranes. Journal of Membrane Science 2005, 251, 51-57.

  • Zhang, K.; Simon, C. G.; Washburn, N. R.; Antonucci, J. M.; Lin-Gibson, S. In Situ Formation of Blends by Photopolymerization of Poly(Ethylene Glycol) Dimethacrylate and Polylactide. Biomacromolecules 2005, 6, 1615-1622.

  • Lin-Gibson, S.; Jones, R. L.; Washburn, N. R.; Horkay, F. Structure-Property Relationships of Photopolymerizable Poly(Ethylene Glycol) Dimethacrylate Hydrogels. Macromolecules 2005, 38, 2897-2902.

  • Caliskan, G.; Mechtani, D.; Roh, J. H.; Kisliuk, A.; Sokolov, A. P.; Azzam, S.; Cicerone, M. T.; Lin-Gibson, S.; Peral, I. Protein and Solvent Dynamics: How Strongly Are They Coupled? Journal of Chemical Physics 2004, 121, 1978-1983.

  • Hobbie, E. K.; Lin-Gibson, S.; Wang, H.; Pathak, J. A.; Kim, H. Ubiquity of Domain Patterns in Sheared Viscoelastic Fluids. Physical Review e 2004, 69.

  • Lin-Gibson, S.; Kim, H.; Schmidt, G.; Han, C. C.; Hobbie, E. K. Shear-Induced Structure in Polymer-Clay Nanocomposite Solutions. Journal of Colloid and Interface Science 2004, 274, 515-525.

  • Lin-Gibson, S.; Bencherif, S.; Cooper, J. A.; Wetzel, S. J.; Antonucci, J. M.; Vogel, B. M.; Horkay, F.; Washburn, N. R. Synthesis and Characterization of PEG Dimethacrylates and Their Hydrogels. Biomacromolecules 2004, 5, 1280-1287.

  • Lin-Gibson, S.; Pathak, J.; Grulke, E.; Wang, H.; Hobbie, E. Elastic Flow Instability in Nanotube Suspensions. Physical Review Letters 2004, vol.92, no.4, 048302-1-048302/4.

  • Lin-Gibson, S.; Pathak, J. A.; Grulke, E. A.; Wang, H.; Hobbie, E. K. Elastic Flow Instability in Nanotube Suspensions. Physical Review Letters 2004, 92.

  • Hobbie, E. K.; Wang, H.; Kim, H.; Lin-Gibson, S.; Grulke, E. A. Orientation of Carbon Nanotubes in a Sheared Polymer Melt. Physics of Fluids 2003, 15, 1196-1202.

  • Lin-Gibson, S.; Walls, H. J.; Kennedy, S. B.; Welsh, E. R. Reaction Kinetics and Gel Properties of Blocked Diisocyinate Crosslinked Chitosan Hydrogels. Carbohydrate Polymers 2003, 54, 193-199.

  • Lin-Gibson, S.; Bencherif, S. A.; Beers, K. L.; Byrd, H. C. M. MALDI-TOF Mass Spectral Characterization of Covalently Cationized Polystyrene. Macromolecules 2003, 36, 4669-4671.

  • Lin-Gibson, S.; Schmidt, G.; Kim, H.; Han, C. C.; Hobbie, E. K. Shear-Induced Mesostructure in Nanoplatelet-Polymer Networks. Journal of Chemical Physics 2003, 119, 8080-8083.

  • Malwitz, M. M.; Lin-Gibson, S.; Hobbie, E. K.; Butler, P. D.; Schmidt, G. Orientation of Platelets in Multilayered Nanocomposite Polymer Films. Journal of Polymer Science Part B-Polymer Physics 2003, 41, 3237-3248.

  • Lin-Gibson, S.; Brunner, L.; Vanderhart, D. L.; Bauer, B. J.; Fanconi, B. M.; Guttman, C. M.; Wallace, W. E. Optimizing the Covalent Cationization Method for the Mass Spectrometry of Polyolefins. Macromolecules 2002, 35, 7149-7156.

  • Lin-Gibson, S.; Baranauskas, V.; Riffle, J. S.; Sorathia, U. Cresol Novolac-Epoxy Networks: Properties and Processability. Polymer 2002, 43, 7389-7398.

  • Lin-Gibson, S.; Glass, T. E.; Shultz, A. R.; Riffle, J. S. Controlled Molecular Weight Cresol-Formaldehyde Oligomers. Polymer 2002, 43, 2017-2029.


Workshop 13: Building Measurement Assurance in Flow Cytometry

Lili Wang, Stephen Perfetto, Robert Hoffman, John T. Elliott, Sheng Lin-Gibson, Steven Bauer, Heba Degheidy, Judith Arcidiacono, Litwin Virginia
Two workshops were held to identify measurement challenges and potential solutions for building measurement assurance for flow cytometry. This report summarizes
Created August 28, 2019