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Michael Nelson

Research Chemist

  • Developed reference material products for organic chemical measurement applications; special expertise for production of organic chemical primary standards for realization of SI measurement units
  • Developed advanced chemical measurement data analysis approaches for metrological applications using computational statistical models and Bayesian inference; Developed automated statistical tools for chemical measurement models and uncertainty estimation to be implemented by chemical analysts
  • Developed quantitative nuclear magnetic resonance techniques and primary standards for establishing metrological traceability of organic chemicals in chemical and biological reference materials, as well as in natural and biological matrices
  • Developed rigorous approaches to confident purity and impurity characterizations of neat organic chemical materials using multiple measurement techniques
  • Investigated and developed 2-dimensional heteronuclear qNMR techniques for large organic chemicals, for classes of compounds with a high degree of structural similarity, and for reference materials with complex organic chemical profiles
  • Represented NIST internationally as a delegate to the Organic Analysis Working Group (OAWG) of the Consultative Committee for Amount of Substance – Metrology in Chemistry (CCQM) Represented ANSI (USA) internationally as a delegate to the International Organization for Standardization Committee on Reference Materials (ISO/REMCO)
  • Served as a member of the United States Pharmacopeia (USP) Expert Panel for Quantitative Nuclear Magnetic Resonance (qNMR) to develop revisions of USP General Chapters <761>, providing USP standard for metrologically sound qNMR methods


  • NIST Delegate, Organic Analysis Working Group (OAWG), Consultative Committee for Amount of Substance – Metrology in Chemistry (CCQM) (2016 – present)
  • Member, ISO/REMCO
  • Member, IUPAC Working Group on Methods for the SI Value Assignment of the Purity of Organic Compounds for Use as Primary Reference Materials and Calibrators (2015 – 2019)
  • Member, USP Expert Panel for Quantitative Nuclear Magnetic Resonance (qNMR) (2019 – Present)


  • Cooperation on International Traceability in Chemistry in Analytical Chemistry, Best Publications Award (2019)
  • U.S. Department of Commerce Bronze Medal Award, National Institute of Standards and
  • Technology (2018)
  • Material Measurement Laboratory Technical Outreach Award, National Institute of Standards and
  • Technology (2017)
  • ACS Student Chemistry Award, American Chemical Society, Maryland Section (2007)


Certification of a pregnancy-specific reference material for thyroid biomarkers, vitamin D, and nutritional trace elements in serum

Ashley S. Boggs-Russell, Lisa E. Kilpatrick, Carolyn Q. Burdette, Denise S. Tevis, Zachary A. Fultz, Michael A. Nelson, Jeff M. Jarrett, Stephen A. Wise, Brittany Kassim, Stephen E. Long
Background Concentrations of critical metabolites, hormones, and nutritional elements change significantly throughout pregnancy. Therefore, increased matrix
Created October 9, 2019, Updated April 30, 2020