Melis Kant

Publications

Functional Analyses of Single Nucleotide Polymorphic Variants of the DNA Glycosylase NEIL1 Present in sub-Saharan African Populations

July 20, 2023

Author(s)

Jamie Zuckerman, Irina Minko, Melis Kant, Pawel Jaruga, Miral M. Dizdar, Amanda McCullough, R. Stephen Lloyd

Nei-like glycosylase 1 (NEIL1) is a DNA repair enzyme that initiates the base excision repair (BER) pathway to cleanse the human genome of damage. Its substrate

Production, purification and characterization of 15N5-labeled cis- and trans-aflatoxin B1-formamidopyrimidines, and aflatoxin B1-N7-guanine as internal standards for mass spectrometric measurements

April 11, 2023

Author(s)

Pawel Jaruga, Melis Kant, Miral M. Dizdar, Rachana Tomar, Vladimir Vartanian, Benjamin Sexton, Carmelo Rizzo, Robert Turesky, Michael Stone, R. Stephen Lloyd

Exposure to aflatoxin B1 (AFB1) through contaminated food is a primary contributor to the occurrence of hepatocellular carcinogenesis worldwide. Hepatitis B

Polymorphic variant Asp239Tyr of human DNA glycosylase NTHL1 is inactive for removal of a variety of oxidatively-induced DNA base lesions from genomic DNA

July 16, 2022

Author(s)

Melis Kant, Victoria Quintana, Erdem Coskun, Pawel Jaruga, R. Stephen Lloyd, Joann Sweasy, Miral M. Dizdar

Base excision repair is the major pathway for the repair of oxidatively-induced DNA damage with DNA glycosylases removing modified DNA bases in the first step

Inhibition by Tetrahydroquinoline Sulfonamide Derivatives of the Activity of Human 8-Oxoguanine DNA Glycosylase (OGG1) for Several Products of Oxidatively-induced DNA Base Lesions

December 17, 2021

Author(s)

Miral M. Dizdar, Melis Kant, Pawel Jaruga, Erdem Coskun, Yu-Ki Tahara, R. S. Lloyd, Eric T. Kool

DNA glycosylases involved in the first step of the base excision repair pathway of DNA repair are promising targets in cancer therapy. There is evidence that

DNA glycosylase deficiency leads to decreased severity of lupus in the Polb-Y265C mouse model

June 24, 2021

Author(s)

Sesha Paluri, Matthew Burak, Alireza Senenjani, Kelly Carufe, Kaylin Clairmont, Isabel Alvarado-Cruz, Rithy Meas, Michael Kashgarian, Caroline Zeiss, Stephen Maher, Alfred Bothwell, Erdem Coskun, Melis Kant, Pawel Jaruga, Miral M. Dizdar, R S. Lloyd, Joann B. Sweasy

The Polb gene encodes DNA polymerase beta (Pol β), a DNA polymerase that functions in base excision repair (BER) and microhomology-mediated end-joining. The Pol

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Melis Kant (IntlAssoc)

Publications