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Displaying 1 - 8 of 8

Functional Analyses of Single Nucleotide Polymorphic Variants of the DNA Glycosylase NEIL1 Present in sub-Saharan African Populations

July 20, 2023
Author(s)
Jamie Zuckerman, Irina Minko, Melis Kant, Pawel Jaruga, Miral M. Dizdar, Amanda McCullough, R. Stephen Lloyd
Nei-like glycosylase 1 (NEIL1) is a DNA repair enzyme that initiates the base excision repair (BER) pathway to cleanse the human genome of damage. Its substrate specificity includes several common base modifications formed under oxidative stress conditions

Possible Genetic Risks from Heat-Damaged DNA in Food

June 1, 2023
Author(s)
Yong Woong Jun, Melis Kant, Erdem Coskun, Pawel Jaruga, Miral M. Dizdar, Eric T. Kool
Consumption of foods prepared at high temperatures has been associated with numerous health risks. To date, the chief identified source of risk has been small molecules produced in trace levels by cooking and react with healthy DNA upon consumption. Here

Production, purification and characterization of 15N5-labeled cis- and trans-aflatoxin B1-formamidopyrimidines, and aflatoxin B1-N7-guanine as internal standards for mass spectrometric measurements

April 11, 2023
Author(s)
Pawel Jaruga, Melis Kant, Miral M. Dizdar, Rachana Tomar, Vladimir Vartanian, Benjamin Sexton, Carmelo Rizzo, Robert Turesky, Michael Stone, R. Stephen Lloyd
Exposure to aflatoxin B1 (AFB1) through contaminated food is a primary contributor to the occurrence of hepatocellular carcinogenesis worldwide. Hepatitis B viral infections in livers dramatically increase the carcinogenic potency of AFB1 exposures. Liver

Polymorphic variant Asp239Tyr of human DNA glycosylase NTHL1 is inactive for removal of a variety of oxidatively-induced DNA base lesions from genomic DNA

July 16, 2022
Author(s)
Melis Kant, Victoria Quintana, Erdem Coskun, Pawel Jaruga, R. Stephen Lloyd, Joann Sweasy, Miral M. Dizdar
Base excision repair is the major pathway for the repair of oxidatively-induced DNA damage with DNA glycosylases removing modified DNA bases in the first step. Among them, human NTHL1 is specific for excision of several pyrimidine- and purine-derived

Inhibition by Tetrahydroquinoline Sulfonamide Derivatives of the Activity of Human 8-Oxoguanine DNA Glycosylase (OGG1) for Several Products of Oxidatively-induced DNA Base Lesions

December 17, 2021
Author(s)
Miral M. Dizdar, Melis Kant, Pawel Jaruga, Erdem Coskun, Yu-Ki Tahara, R. S. Lloyd, Eric T. Kool
DNA glycosylases involved in the first step of the base excision repair pathway of DNA repair are promising targets in cancer therapy. There is evidence that reduction of their activities may enhance cell killing in malignant tumors. Recently, two

DNA glycosylase deficiency leads to decreased severity of lupus in the Polb-Y265C mouse model

June 24, 2021
Author(s)
Sesha Paluri, Matthew Burak, Alireza Senenjani, Kelly Carufe, Kaylin Clairmont, Isabel Alvarado-Cruz, Rithy Meas, Michael Kashgarian, Caroline Zeiss, Stephen Maher, Alfred Bothwell, Erdem Coskun, Melis Kant, Pawel Jaruga, Miral M. Dizdar, R S. Lloyd, Joann B. Sweasy
The Polb gene encodes DNA polymerase beta (Pol β), a DNA polymerase that functions in base excision repair (BER) and microhomology-mediated end-joining. The Pol β-Y265C protein exhibits low catalytic activity and fidelity, and is also deficient in

Ne-22 Ion-Beam Radiation Damage to DNA: From Initial Free Radical Formation to Resulting DNA-Base Damage

June 14, 2021
Author(s)
Melis Kant, Pawel Jaruga, Erdem Coskun, Samuel Ward, Alexander Stark, Thomas Baumann, David Becker, Amitava Adhikary, Michael Sevilla, Miral M. Dizdar
We report on the physicochemical processes and the products of DNA damage involved in Ne-22 ion-beam radiation of hydrated (12±3 H2O/nucleotide) salmon sperm DNA at 77 K. Free radicals trapped at 77 K were identified using electron spin resonance (ESR)

Ion-beam radiation damage to DNA by investigation of free radical formation and base damage

March 1, 2020
Author(s)
Melis Kant, Pawel Jaruga, Erdem Coskun, Samuel Ward, Alexander Stark, David Becker, Amitav Adhikary, Michael Sevilla, Miral M. Dizdar
This work investigated the physicochemical processes and DNA base products involved in Ne-22 ion- beam (ca. 1.4 GeV) radiation damage to hydrated (12 waters/nucleotide) highly polymerized salmon sperm DNA. For this purpose, approximately 12 small (ca. 10