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Mandy Esch

Mandy B. Esch is a project leader in the Microsystems and Nanotechnology Division. She received an M.S. in Biology and a Ph.D. in Biotechnology from the Julius Maximilians (Würzburg) University in Germany. During her PhD research she developed paper-microfluidics and microfluidic biosensors for the detection of pathogens that can contaminate drinking water. In 2001, Mandy joined the Cornell Nanoscale Science and Technology Facility as life sciences liaison, where she helped create nanobiotechnology projects. In 2007, she joined the department of Biomedical Engineering at Cornell University as a senior research associate. While there, she developed several patents for multi-organ body-on-a-chip systems. For this work, her team received the 2015 Lush Science Prize. From 2015 to 2016 Mandy spent a year as an assistant professor at Syracuse University at the Department of Biomedical and Chemical Engineering. She taught nanobiotechnology and built a laboratory for tissues-on-chip research. In 2016 Mandy moved to Maryland, where she joined NIST. Her work at NIST will focus on integrating tissue sensors with tissues-on-a-chip devices.

Selected Publications


Biodegradable biliverdin nanoparticles for efficient photoacoustic imaging

Parinaz Fathi, Knox J. Hailay, Dinabandhu Sar, Indu Tripathi, Ostadhossein Fatemeh, Misra K. Santosh, Mandy B. Esch, Jefferson Chan, Dipanjan Pan
Here we report the synthesis of nanoparticles composed of Biliverdin cross-linked with a bifunctional amine functionalized linker. The nanoparticles display

Self-contained, Low Cost “Body-on-a-Chip” Systems for Drug Development

Ying Wang, Oleaga Carlota, Long Christopher, McAleer Christopher, Paula Miller, James J. Hickman, Michael L. Shuler, Mandy B. Esch
Integrated multi-organ microphysiological systems are an evolving tool for preclinical evaluation of the potential toxicity and efficacy of drug candidates
Created September 10, 2019, Updated May 18, 2020