Mandy B. Esch is a CNST project leader in the Biomedical Microtechnologies Group. She received an M.S. in Biology and a Ph.D. in Biotechnology from the Julius Maximilians (Würzburg) University in Germany. During her PhD research she developed paper-microfluidics and microfluidic biosensors for the detection of pathogens that can contaminate drinking water. In 2001, Mandy joined the Cornell Nanoscale Science and Technology Facility as life sciences liaison, where she helped create nanobiotechnology projects. In 2007, she joined the department of Biomedical Engineering at Cornell University as a senior research associate. While there, she developed several patents for multi-organ body-on-a-chip systems. For this work, her team received the 2015 Lush Science Prize. From 2015 to 2016 Mandy spent a year as an assistant professor at Syracuse University at the Department of Biomedical and Chemical Engineering. She taught nanobiotechnology and built a laboratory for tissues-on-chip research. In 2016 Mandy moved to Maryland, where she joined NIST. Her work at NIST will focus on integrating tissue sensors with tissues-on-a-chip devices.
- Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue, M.B. Esch, H. Ueno, D.R. Applegate, M.L. Shuler, Lab on a Chip, 2016, 16 (14), 2719-2729.
- Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs, C. Oleaga, C. Bernabini, A.S.T. Smith, B. Srinivasan, M. Jackson, W. McLamb, V. Platt, R. Bridges, Y. Cai, N. Santhanam, B. Berry, S. Najjar, N. Akanda, X. Guo, C. Martin, G. Ekman, M. B. Esch, J. Langer, G. Ouedraogo, J. Cotovio, L. Breton, M. L. Shuler, J. J. Hickman, Scientific Reports, 2016, 6, 1-17.
- Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow, M.B. Esch, J.M. Prot, Y.I. Wang, P. Miller, J.R. Llamas-Vidales, B.A. Naughton, D. Applegate, M.L. Shuler, Lab on a Chip, 2015, 15 (10), 2269-2277.
- Endothelial retention and phenotype on carbonized cardiovascular implant surfaces, C.M. Frendl, S.M. Tucker, N.A. Khan, M.B. Esch, S. Kanduru, T.M. Cao, J. Butcher, Biomaterials, 2014, 35 (27), 7714-7723.
- How multi-organ microdevices can help foster drug development, M.B. Esch, A.S.T. Smith, J.M. Prot, C. Oleaga, J.J. Hickman, M.L. Shuler, Advanced Drug Delivery Reviews, 2014, 69, 158-169.
- Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury, M.B. Esch, G.J. Mahler, T. Stokol, M.L. Shuler, Lab on a Chip, 2014, 14 (16), 3081-3092.
- Microfabricated mammalian organ systems and their integration into models of whole animals and humans, J.H. Sung, M.B. Esch, J.M. Prot, C.J. Long, A. Smith, J.J. Hickman, M.L. Shuler, Lab on a Chip, 2013, 13 (7), 1201-1212.
- On chip porous polymer membranes for integration of gastrointestinal tract epithelium with microfluidic ‘body-on-a-chip’devices, M.B. Esch, J.H. Sung, J. Yang, C. Yu, J. Yu, J.C. March, M.L. Shuler, Biomedical Microdevices, 2012, 14 (5), 895-906.
- Oral exposure to polystyrene nanoparticles affects iron absorption, G.J. Mahler, M.B. Esch, E. Tako, T.L. Southard, S.D. Archer, R.P. Glahn, M.L. Shuler, Nature Nanotechnology 7 (4), 264-271.
- Characterization of in vitro endothelial linings grown within microfluidic channels, M.B. Esch, D.J. Post, M.L. Shuler, T. Stokol, Tissue Engineering Part A, 2011, 17 (23-24), 2965-2971.
- The role of body-on-a-chip devices in drug and toxicity studies, M.B. Esch, T.L. King, M.L. Shuler, Annual Review of Biomedical Engineering, 2011 13, 55-72.