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Mandy Esch (Fed)

Mandy B. Esch is a project leader in the Microsystems and Nanotechnology Division. She received an M.S. in Biology and a Ph.D. in Biotechnology from the Julius Maximilians University in Würzburg, Germany. During her PhD research she developed paper-based microfluidics and microfluidic biosensors for the detection of pathogens. In 2001, Dr. Esch joined the Cornell Nanoscale Science and Technology Facility as life sciences liaison. In 2007, she joined the department of Biomedical Engineering at Cornell University as a senior research associate. While there, she developed several patents for multi-organ body-on-a-chip systems. As part of a team that develops MPS systems, she received the 2015 Lush Science Prize. From 2015 to 2016 Dr. Esch spent a year as an assistant professor at Syracuse University at the Department of Biomedical and Chemical Engineering. She taught nanobiotechnology and built a laboratory for tissues-on-chip research. In August of 2016 Dr. Esch moved to NIST, where she is focusing on integrating sensors with tissues-on-a-chip and MPS devices.

NRC postdoc opportunities

We are looking for postdocs with expertise in the development of on organs-on-chips, MPS, and PBPK modelling. Please contact Dr. Esch via email, or read about the NRC opportunity here.

Selected Publications


Patents (2018-Present)

Body Cube And Process For Culturing Tissue

NIST Inventors
Mandy Esch
A body cube for culturing tissue that includes: an organ chip holder; and a body barrier chip and a first body organ chip disposed in the organ chip holder, the first body organ chip including a first cell culture chamber that receives cell culture medium and produces a first tissue in the first

Body Cube And Process For Culturing Tissue

NIST Inventors
Mandy Esch
This invention describes a microphysiologic body cube that holds multiple organ chips and that can be operated with near physiologic amounts of blood surrogate. The invention can be used to culture multiple tissues with near-physiologic amounts of blood surrogate within one systems. Microphysiologic
Created September 10, 2019, Updated December 8, 2022