Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Darwin Reyes-Hernandez (Fed)

Dr. Reyes-Hernandez is a biomedical engineer in the Microsystems and Nanotechnology Division of the Physical Measurement Laboratory (PML) at the National Institute of Standards and Technology (NIST). He received a B.S. and Ph.D. in chemistry from the University of Puerto Rico, and an M.S. in Applied Biomedical Engineering from Johns Hopkins University. In his doctoral work, he combined the fields of environmental analytical chemistry and toxicology. In it, he chemically characterized airborne particulate matter from an area in Puerto Rico of high incidence of cancer, asthma, and other respiratory diseases, using cell-based toxicological assays. After completing his Ph.D. he was awarded with a National Science Foundation (NSF) Postdoctoral Fellowship to work with Professor Andreas Manz at Imperial College, London, U.K., where he worked for two years. During this postdoctoral experience, he worked with microfluidic devices in developing two-dimensional separation systems and analog computing using glow discharge in microfluidic chips.  

Dr. Reyes-Hernandez was awarded in 2002 with a National Research Council/NIST postdoctoral fellowship to work at NIST, USA.  He is currently working in the development of microfluidic systems with electronic manipulation and measurement for cell-based assays and drug screening; electronic flow measurement sensors/methods; cell-substrate biomimetic interfaces with tunable elasticity; additive manufacturing (3D Printing) using fused deposition modeling (FDM) for microfluidic devices; and thin, flexible wearable sensors.

During his time at NIST, Dr. Reyes-Hernandez has been part of various intramural funded projects including research funded by the Advanced Technology Program (ATP), Director's Reserve Funds, Innovations in Measurement Science Program (IMS) and more recently, the NIST on a Chip Initiative.



Selected Publications


Overcoming Technological Barriers in Microfluidics: Leakage Testing

Vania Silverio, Suvajyoti Guha, Armelle Keiser, Rucha Natu, Darwin Reyes-Hernandez, Henne van Heeren, Nicolas Verplanck, Luke Herbertson
The miniaturization of laboratory procedures for Lab-on-Chip (LoC) devices and translation to various platforms such as single cell analysis or Organ-on-Chip

Protocols for leakage testing

Henne van Heeren, Matthew Davies, Armelle Keiser, Rudy Lagrauw, Darwin Reyes-Hernandez, Vania Silverio, Nicolas Verplanck
This document is written to serve as a guideline for the testing of microfluidic devices, which are devices designed to manipulate fluids that are confined in a

Amontons-Coulomb-like slip dynamics in acousto-microfluidics

Aurore F. Quelennec, Jason J. Gorman, Darwin Reyes-Hernandez
Electroacoustic technologies, which employ acoustic waves to manipulate and detect bioparticles, have been increasingly used, with a great deal of success, in

Patents (2018-Present)

Duel Dielectropheretic Membrane for Monitoring Cell Migration

NIST Inventors
Darwin Reyes-Hernandez
A dual dielectropheretic article for monitoring cell migration includes: a membrane to selectively migrate a plurality of cells across the membrane, the membrane including: a first surface to receive the cells; a second surface opposed to the first surface; and a plurality of communication paths
Created April 29, 2019, Updated April 5, 2024