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Christina Jones

Metabolomics is the methodical scientific study of biochemical processes associated with the metabolome—which comprises the entire collection of metabolites in any biological entity. Accordingly, metabolomics is critical for probing changes in metabolite levels and collecting pertinent metabolic pathway information in an effort to investigate the biochemical fingerprints specific to particular cellular processes. Metabolome changes occur after modifications of the genome and proteome, and are, consequently, more directly related to cellular phenotype. Thus, metabolomic analysis is capable of providing a snapshot of cellular physiology.

As the field of metabolomics rapidly advances, there has been a parallel expansion of different measurement platforms capable of evaluating a broad range of diverse metabolites. Moreover, the immensity of metabolomics research leads to the introduction of many sources of variance throughout experimental workflows. Consequently, analytical data from instrumental platforms can be more variable than the actual biological changes being probed. It has become vital for NIST to engage the metabolomics community in measurement harmonization efforts in order to confirm, validate, and commercially translate biological discoveries. My work involves developing quality assurance and quality control materials and data to improve the comparability of metabolomics measurements across all sectors of the metabolomics community.

Professional Awards and Recognition

  • National Research Council Postdoctoral Fellowship, 2015
  • Facilitating Academic Careers in Engineering and Science (FACES) Fellowship, 2009–2013
  • President's Fellowship, Georgia Institute of Technology, 2009–2013
  • Undergraduate Award in Analytical Chemistry, LSU & ACS Division of Analytical Chemistry, 2009
  • Phi Beta Kappa Society, 2009
  • Outstanding Research Achievement Award, LSU Department of Chemistry, 2009
  • United Negro College Fund/Merck Undergraduate Science Research Scholarship Award, 2008
  • Howard Hughes Medical Institute Exceptional Research Opportunities Program (HHMI EXROP), 2007
  • American Chemical Society Scholars Program, 2007–2009

Professional Activities

  • Member of the American Society for Mass Spectrometry
  • Member of the National Organization of Black Chemists and Chemical Engineers
  • Member of the Metabolomics Society
  • Member of the Metabolomics Quality Assurance and Quality Control Consortium (mQACC)

Publications

Towards quality assurance and quality control in untargeted metabolomics studies

Author(s)
Richard Beger, Warwick Dunn, Abbas Bandukwala, Bianca Bethan, David Broadhurst, Clary Clish, Surendra Dasari, Leslie Derr, Annie Evans, Steve Fischer, Thomas Flynn, Thomas Hartung, David Herrington, Richard Higashi, Ping-Ching Hsu, Christina M. Jones, Maureen Kachman, Helen Karuso, Gary Kruppa, Katrice A. Lippa, Padma Maruvada, Jonathan Mosley, Ionna Ntai, Clair O?Donovan, Mary Playdon, Daniel Raftery, Daniel Shaughnessy, Amanda Souza, Timothy Spaeder, Barbara Spalholz, Mukesh Verma, Tilman Walk, Ian Wilson, Daniel Bearden, Krista Zanetti
We describe here the agreed upon first development steps and priority objectives of a community engagement effort to address current challenges in quality

Examining Heat Treatment for Stabilization of the Lipidome

Author(s)
John Bowden, Candice Z. Ulmer, Christina M. Jones, Tracey B. Schock, Jeremy P. Koelmel, Timothy J. Garrett, Richard A. Yost
Aim: To confidently determine lipid-based biomarkers, it is important to minimize variation introduced during preanalytical steps. We evaluated reducing
Created August 27, 2019