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Anthony J. Kearsley ()

Publications

Patents (2018-Present)

Agile Nucleic Acid Sensor And Measuring A Biomarker

NIST Inventors
Kevin Kiesler , Alokik Kanwal , Anthony J. Kearsley , Erica Romsos , Peter M. Vallone , Jacob Majikes and Arvind Balijepalli
An agile nucleic acid sensor includes: a DNA switch; an analysis substrate in electrostatic communication with the DNA switch and that produces a biomarker electrical signal; a transduction member that receives the biomarker electrical signal and produces a transduction signal; a sensor counter

System And Method For Data Analysis In Quantitative PCR Measurements

NIST Inventors
Anthony J. Kearsley , Paul Patrone , Erica Romsos and Peter M. Vallone
In quantitative polymerase chain-reaction (qPCR) measurements, accurately subtracting background signals, quantifying the amount of DNA, and ensuring fidelity of data analysis and diagnostic tests is challenging. Such problems are especially acute for emerging / novel diseases that lack thoroughly

Serial Cytometry

NIST Inventors
Gregory A Cooksey , Paul Patrone and Anthony J. Kearsley
Flow cytometers can make thousands of single-cell measurements per second, but the limited ability to quantify uncertainty in individual measurements reduces their effectiveness for characterizing biomarker distributions, discriminating cell populations, and detecting rare events. To facilitate

Multiplexed Amplitude Modulation Fluorometry

NIST Inventors
Anthony J. Kearsley , Gregory A Cooksey and Paul Patrone
Improving accuracy of cytometers is challenging because optical configuration, flow control methods, and calibration issues make it difficult to characterize geometric factors associated with signal collection. State-of-the-art tools only collect a small solid angle of emitted light, so that minor
Created October 9, 2019, Updated December 8, 2022