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Anthony J. Kearsley (Fed)

Publications

Opioid sensing at point-of-need

Author(s)
Thinh Bui, Edward Sisco, Kyle Chapkin, Wenqi Zhu, Junyeob Song, Dhruv Forma, Anthony Kearsley, Henri Lezec
The opioid epidemic, headlined by synthetic fentanyl, is a growing international concern that has especially garnered great attention in the United States at...

Topological Initialization for Multidimensional Scaling

Author(s)
Melinda Kleczynski, Anthony Kearsley
Multidimensional scaling is a popular technique for visualizing dissimilarities between objects in complex datasets. For a single dataset, different initial...
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Patents (2018-Present)

Agile Nucleic Acid Sensor And Measuring A Biomarker

NIST Inventors
Kevin Kiesler , Alokik Kanwal , Anthony J. Kearsley , Erica Romsos , Peter M. Vallone and Jacob Majikes
An agile nucleic acid sensor includes: a DNA switch; an analysis substrate in electrostatic communication with the DNA switch and that produces a biomarker electrical signal; a transduction member that receives the biomarker electrical signal and produces a transduction signal; a sensor counter

System And Method For Data Analysis In Quantitative PCR Measurements

NIST Inventors
Anthony J. Kearsley , Erica Romsos and Peter M. Vallone
In quantitative polymerase chain-reaction (qPCR) measurements, accurately subtracting background signals, quantifying the amount of DNA, and ensuring fidelity of data analysis and diagnostic tests is challenging. Such problems are especially acute for emerging / novel diseases that lack thoroughly
Serial cytometry involves making repeated measurements of single objects as they pass through multiple interrogation regions in a microfluidic channel. Integrated optical waveguides deliver and collect light from objects. Matching and analysis of signals from individual cells, for example, enable uncertainty estimates on the biomarker content of each cell, which enables better comparison and classification of cells and mixture of cells.

Serial Cytometry

NIST Inventors
Gregory A Cooksey and Anthony J. Kearsley
NIST scientists have developed a microfluidic flow cytometer that is capable of robust and repeated measurements that provide first-of-their-kind uncertainty estimates, which support better comparability and classification of cytometry data. The device measures single objects in flow several times

Multiplexed Amplitude Modulation Fluorometry

NIST Inventors
Anthony J. Kearsley and Gregory A Cooksey
Improving accuracy of cytometers is challenging because optical configuration, flow control methods, and calibration issues make it difficult to characterize geometric factors associated with signal collection. State-of-the-art tools only collect a small solid angle of emitted light, so that minor
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Created October 9, 2019, Updated December 8, 2022
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