Skip to main content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Alexander Peterson

Research Chemist

Research Interests:

My research interests are to help develop and add measurement confidence to modern microscopy techniques based on physical measurement microscopy, techniques that measure the intrinsic optical properties of cells in a live-cell, label-free, non-destructive format.  These intrinsic properties (refractive index, absorbance, scattering) are directly derived into cellular physical properties: mass, volume, density, and growth.  These are critical cell-based measurement needs!  These properties are traceable, derived from SI units, and amenable to the use of reference materials to aid in measurement reproducibility and comparability. 

Most microscopy strategies are observational and current technology relies on fundamentally qualitative techniques.   It cannot escape from human subjectivity.  

I am most interested in physical microscopy techniques such as surface plasmon resonance imaging, quantitative phase imaging, and enhanced darkfield imaging.  Basic research, clinical assays, and biomanufacturing industry need measurement techniques like these that are reproducible, quantitative and non-invasive.

 

Physical Microscopy Properties and Techniques
Credit: Alexander Peterson
Physical microscopy techniques allow for measurement of physical  properties and are amenable for reference material artifacts.

 

Interested in a NIST-NRC Postdoctoral Fellowship?

2-year fellowship at NIST on the topic of:
Design, development and evaluation of surface plasmon resonance imaging as a quantitative microscopy of live cells and their extracellular environment.
Contact alexander.peterson [at] nist.gov (Alexander Peterson) if interested in applying and writing a proposal (3000 words).  Application deadlines Feb. 1 and Aug. 1. Open to U.S. citizens, $71,128 stipend plus benefits, relocation expenses included.

Publications

Agglomeration of Escherichia coli with positively charged nanoparticles can lead to artifacts in a standard Caenorhabditis elegans toxicity assay

Author(s)
Shannon Hanna, Antonio R. Montoro Bustos, Alexander W. Peterson, Vytautas Reipa, Leona D. Scanlan, Sanem Hosbas Coskun, Tae Joon Cho, Monique E. Johnson, Vincent A. Hackley, Bryant C. Nelson, Michael R. Winchester, John T. Elliott, Elijah J. Petersen
The increased use and incorporation of engineered nanoparticles (ENPs) in consumer products requires a robust assessment of their potential environmental
Created October 9, 2019, Updated November 14, 2019