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Charge Detector And Process For Sensing A Charged Analyte

Patent Number: 11,493,476

Abstract

A charge detector includes: a charge sensor that senses a charged analyte and produces a charge signal in response to contact with the charged analyte; a transducer in electrical communication with the charge sensor and that: receives the charge signal from the charge sensor, receives a feedback control signal; and produces a transduction signal in response to receipt of the charge signal and the feedback control signal; and a sensitivity controller in electrical communication with the transducer and that: receives the transduction signal from the transducer; produces the feedback control signal in response to receipt of the transduction signal from the transducer; and produces a charge readout in response to receipt of the transduction signal from the transducer.

patent description

(1) Disclosed is a charge detector to operate a dual-gated field effect transistor at a quantum capacitance limit for performing ultrasensitive biosensing, the charge detector comprising: a charge sensor that senses a charged analyte and produces a charge signal in response to contact with the charged analyte; a transducer in electrical communication with the charge sensor and that: receives the charge signal from the charge sensor, receives a feedback control signal; and produces a transduction signal in response to receipt of the charge signal and the feedback control signal; and a sensitivity controller in electrical communication with the transducer and that: receives the transduction signal from the transducer; produces the feedback control signal in response to receipt of the transduction signal from the transducer; and produces a charge readout in response to receipt of the transduction signal from the transducer.

(2) Disclosed is a process for sensing a charged analyte, the process comprising: contacting the charge sensor with the charged analyte; producing, by the charge sensor, the charge signal; communicating the charge signal from the charge sensor to the transducer, receiving, by the transducer, the charge signal from the charge sensor, receiving, by the transducer, the feedback control signal from the sensitivity controller; producing, by the transducer, the transduction signal in response to receipt of the charge signal; receiving, by the sensitivity controller, the transduction signal from the transducer; and producing, by the sensitivity controller, the charge readout in response to receipt of the transduction signal to sense the charged analyte.

(3) Disclosed is a dual gate field effect transistor to sense an analyte, the dual gate field effect transistor comprising: an analyte gate; a transition metal dichalcogenide layer disposed on the analyte gate and comprising a transition metal dichalcogenide; a source electrode disposed on the two-dimensional active layer and in electrical communication with the two-dimensional active layer; a drain electrode disposed on the two-dimensional active layer and in electrical communication with the two-dimensional active layer and in electrical communication with the source electrode via the two-dimensional active layer; and a control gate disposed on the two-dimensional active layer and controlling the communication of electrical current in the two-dimensional active layer between the source electrode and the drain electrode, wherein the electrical current communicated in the two-dimensional active layer is changed in response to a change in an electrical charge present at the analyte gate due to the analyte.

(4) Also disclosed is a process for sensing an analyte, the process comprising: providing the dual gate field effect transistor; subjecting the source electrode and the drain electrode with a first potential difference comprising a drain voltage; subjecting the control gate with a gate voltage; and monitoring a drain current to sense a presence of the analyte at the analyte gate.

Created February 2, 2023, Updated December 15, 2023