Simona Patange (Fed)

Dr. Patange is a Staff Biologist with the NIST Material Measurement Laboratory, Biosystems and Biomaterials Division. Her project areas focus on single-cell manipulation technologies and quantitative single-cell metrics to characterize the on- and off- target activity of CRISPR/Cas genome editing systems. She coordinates projects on cell-based specificity measurements for the NIST Genome Editing Program and NIST Genome Editing Consortium. 

RESEARCH AREAS

• Single-cell manipulation & measurement technologies
• Genome editing measurement assurance
• CRISPR-Cas editing systems
• Gene expression analysis in edited cell systems
• NIST Genome in a Bottle cell characterization measurements

PROFESSIONAL ACTIVITIES

• Chair, 2023 MML Accolades Review Committee
• Co-chair, SPMConnect at TechConnect World Conference (website)
• Co-organizer, NIH Light Microscopy Interest Group Seminar Series (website)
• Technical Reviewer, Small Business Innovation Research (SBIR) Program (website)

NIST PROJECT PAGES

• NIST Genome Editing Program
• Single-cell Manipulation and Measurement
• NIST Genome Editing Consortium: Working Group 1 - Specificity Measurements

PUBLICATIONS

Google Scholar Profile

Patange S, Miller SD, Maragh S. “Variability in genome-engineering source materials: Consider your starting point.” Synthetic Biology, 2023, 8(1): ysad003. https://doi.org/10.1093/synbio/ysad003

Patange S, Maragh S. Fire Burn and Cauldron Bubble: What Is in Your Genome Editing Brew? ACS Biochemistry 2022, Article ASAP. https://doi.org/10.1021/acs.biochem.2c00431

Patange S, Ball DA, Wan Y, Karpova TS, Girvan M, Levens D, Larson DR. MYC amplifies gene expression through global changes in transcription factor dynamics, Cell Reports, 2022, 38(4): 110292. https://doi.org/10.1016/j.celrep.2021.110292

Patange S, Ball DA, Karpova TS, Larson DR. Towards a ‘spot on’ understanding of transcription in the nucleus. Journal of Molecular Biology, 2021, 433:167016. https://doi.org/10.1016/j.jmb.2021.167016

Patange S, Girvan M, Larson DR. Single-cell systems biology: Probing the basic unit of information flow. Current Opinion in Systems Biology, 2018, 8:7-15. https://doi.org/10.1016/j.coisb.2017.11.011

Martina M, Diab H, Jeong-A L, Lishu L, Patange S, Raben N, Puertollano R. The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris. Science Signaling, 2014, 7:1-15. https://doi.org/10.1126/scisignal.2004754

• Finalist, Postdoc and Early-Career Association of Researchers (PEAR) Technical award (2023)
• National Research Council Postdoctoral Research Associateship (2022-2022)