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Simona Patange (Fed)

Biologist

Dr. Patange is a Staff Biologist with the NIST Material Measurement Laboratory, Biosystems and Biomaterials Division. Her project areas focus on single-cell manipulation technologies and quantitative single-cell metrics to characterize the on- and off- target activity of CRISPR/Cas genome editing systems. She coordinates projects on cell-based specificity measurements for the NIST Genome Editing Program and NIST Genome Editing Consortium

 

RESEARCH AREAS

  • Single-cell manipulation & measurement technologies
  • Genome editing measurement assurance
  • CRISPR-Cas editing systems
  • Gene expression analysis in edited cell systems
  • NIST Genome in a Bottle cell characterization measurements

 

PROFESSIONAL ACTIVITIES

  • Chair, 2023 MML Accolades Review Committee
  • Co-chair, SPMConnect at TechConnect World Conference (website)
  • Co-organizer, NIH Light Microscopy Interest Group Seminar Series (website)
  • Technical Reviewer, Small Business Innovation Research (SBIR) Program (website)

 

NIST PROJECT PAGES

 

PUBLICATIONS

Google Scholar Profile

Patange S, Miller SD, Maragh S. “Variability in genome-engineering source materials: Consider your starting point.” Synthetic Biology, 2023, 8(1): ysad003. https://doi.org/10.1093/synbio/ysad003

Patange S, Maragh S. Fire Burn and Cauldron Bubble: What Is in Your Genome Editing Brew? ACS Biochemistry 2022, Article ASAP. https://doi.org/10.1021/acs.biochem.2c00431

Patange S, Ball DA, Wan Y, Karpova TS, Girvan M, Levens D, Larson DR. MYC amplifies gene expression through global changes in transcription factor dynamics, Cell Reports, 2022, 38(4): 110292. https://doi.org/10.1016/j.celrep.2021.110292

Patange S, Ball DA, Karpova TS, Larson DR. Towards a ‘spot on’ understanding of transcription in the nucleus. Journal of Molecular Biology, 2021, 433:167016. https://doi.org/10.1016/j.jmb.2021.167016

Patange S, Girvan M, Larson DR. Single-cell systems biology: Probing the basic unit of information flow. Current Opinion in Systems Biology, 2018, 8:7-15. https://doi.org/10.1016/j.coisb.2017.11.011

Martina M, Diab H, Jeong-A L, Lishu L, Patange S, Raben N, Puertollano R. The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris. Science Signaling, 2014, 7:1-15. https://doi.org/10.1126/scisignal.2004754

Awards

  • Finalist, Postdoc and Early-Career Association of Researchers (PEAR) Technical award (2023)
  • National Research Council Postdoctoral Research Associateship (2022-2022)

Publications

Interlaboratory Assessment of Candidate Reference Materials for Lentiviral Vector Copy Number and Integration Site Measurements

Author(s)
Hua-Jun He, Zhiyong He, Steven Lund, Barbara Paugh, Jennifer McDaniel, Justin Zook, Sierra Miller, Samantha Maragh, Simona Patange, Mahir Mohiuddin, Alessandro Tona, John Elliott, Kenneth Cole, Sheng Lin-Gibson
Reference materials are essential for accurately measuring integrated lentiviral vector (LV) copy number (VCN) and integration sites for the safety and efficacy
Created December 9, 2020, Updated February 5, 2024
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