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Workshop on Measurement Needs for Biofabrication of Tissue Engineered Medical Products

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EVENT BROCHURE

Goal: discuss and identify measurement needs for characterizing biofabricated, tissue engineered medical products for clinical applications.

Scope: Biofabricated tissue-engineered constructs have the potential to transform personalized medicine. However, characterizing these constructs post-fabrication and throughout preclinical use remains challenging. We will hold a 1-day workshop on measurement needs for biofabricated constructs that contain cells, focusing on metrology for the structure of the constructs, cell viability in the constructs, and functional capacity of the constructs. This workshop will enable future research directions, standards development, and the adoption of these constructs for clinical use.

 

TECHNICAL PROGRAM

Thursday, December 1, 2022

10:00 AM

11:00 AM

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11:00 AM

11:10 AM

Welcome Address: Sheng Lin Gibson, NIST

11:10 AM

11:45 AM

Plenary: Manufacturing complex biologics for regenerative medicine
Jennifer H. Elisseeff, Johns Hopkins University

Session 1: Cell Viability
Discussion leader: Alicia Henn, BioSpherix

     

11:55 AM

12:05 PM

Non-invasive non-contact real-time monitoring of cells within bio-reactors by direct imaging with optical coherence tomography
Naresh Menon, ChromoLogic

12:05 PM

12:15 PM

Nondestructive Cell viability assessment using oxygen imaging
Mrignayani Kotecha, O2M Technologies

12:15 PM

12:25 PM

Optical coherence tomography imaging for label-free measurement of cell viability in scaffolds
Carl Simon, NIST

12:25 PM

12:55 PM

Panel Discussion

12:55 PM

1:25 PM

Lunch

Session 2: Cell Phenotype
Discussion leader: Jeff Halpern, University of New Hampshire

1:25 PM

1:35 PM

Advancing Drug Discovery with Biofabricated 3D Tissue Models
Marc Ferrer, NCATS

1:35 PM

1:45 PM

Protein Sensing
Marcie Black, Advanced Silicon Group

1:45 PM

1:55 PM

Non-invasive quantitative live cell imaging
Kersti Alm, Phase Holographic Imaging

1:55 PM

2:25 PM

Panel Discussion

2:25 PM

2:35 PM

Break

Session 3: Tissue Characterization
Discussion leader: Nathan Castro, Nanochon Inc.

2:35 PM

2:45 PM

Dielectric spectroscopy for in line monitoring of engineered tissue constructs
Rohan Shirwaiker, North Carolina State University

2:45 PM

2:55 PM

Title: In situ volumetric imaging and analysis of 3D bioprinted constructs using optical coherence tomography
Adam Feinberg, FluidForm

2:55 PM

3:05 PM

Characterization of tissue engineered medical products
Bao-Ngoc Nguyen, FDA

3:05 PM

3:35 PM

Panel Discussion

3:35 PM

3:45 PM

Break

3:45 PM

3:55 PM

Workshop Survey Review, Carl Simon

Breakout Session

Topics and Discussion Leaders

1. Potency & phenotype measurements; Richard McFarland, ARMI
2. Cell viability measurements; Mary Clare McCorry, ARMI
3. Measurements of construct structure; Kimberlee Potter, VA and Leanne Friedrich, NIST
4. pH, O2 & metabolite measurements;
Zeeshan Ahmed, NISTand Billyde Brown, GTMI
5. Mechanical property measurements; Callie Higgins, NIST
6. Sterility measurements; Kirsten Parratt, NIST
7. Measurements of cell distribution in constructs; Taneka Jones, Vericel
8. Measurements of raw materials; Rohan Shirwaiker, NC State University
9. Scaffold reference material; Dawn Henke, Standards Coordinating Body
10. Tissue mimics; Lexi Garcia, ARMI
11. Tissue reference data; Kaiming Ye, Binghamton University

3:55 PM

4:35 PM

Breakout session

Closing Session

4:35 PM 4:55 PM Report back

4:55 PM

5:00 PM

Closing Remarks
Greta Babakhanova, NIST

Mrignayani Kotecha - President, O2M Technologies

Naresh Menon - CEO, ChromoLogic

Jennifer H. Elisseeff - Professor, Johns Hopkins University

Bao-Ngoc Nguyen - Biomedical Engineer, FDA

Adam Feinberg - CTO, FluidForm

Rohan Shirwaiker - Professor, NC State University

Kersti Alm - CSO, Phase Holographic Imaging

Carl G. Simon, Jr. - Biologist, National Institute of Standards and Technology

Marcie Black - Co-founder & CEO, Advanced Silicon Group

Marc Ferrer - Director, 3D Tissue Bioprinting Laboratory, NCATS

Workshop Steering Committee

First name

Last name

Organization

Greta

Babakhanova

National Institute of Standards and Technology

Carl

Simon

National Institute of Standards and Technology

Eugenia

Romantseva

National Institute of Standards and Technology

Laura

Pierce

National Institute of Standards and Technology

Callie

Higgins

National Institute of Standards and Technology

Leanne

Friedrich

National Institute of Standards and Technology

Jonathan

Seppala

National Institute of Standards and Technology

Jay

Hoying

Advanced Solutions

Kimberlee

Potter

U.S. Department of Veterans Affairs

Mary Clare

McCorry

ARMI BioFabUSA

Guillermo

Ameer

Northwestern University

John

Huang

TheWell Bioscience, Inc.

Itedale Namro

Redwan

CELLINK

Dawn

Henke

Standards Coordinating Body

Taneka

Jones

Vericel

Marian

Piekarczyk

Thermofisher

Rohan

Shirwaiker

NC State University

Created September 14, 2022, Updated November 29, 2022