The 2021 joint conference on International Scanning Probe Microscopy (ISPM) and Scanning Probe Microscopy on Soft and Polymeric Materials (SPMonSPM) aims to unite a broad cross-section of scanning probe microscopy (SPM) researchers from around the world. The conference represents a merger of the 22nd hosting of ISPM and the 5th hosting of SPM on SPM. The conference will bring together users ranging from biology, polymer science, energy, computing and beyond, linked by a common interest in the role of SPM to elucidate new physical and chemical phenomena. Junior and senior researchers from industry, academia and government institutions will present their latest developments. The environment will foster new ideas and collaborations across multiple disciplines. The virtual format will include live plenary sessions, live topical invited panels with expert moderators, prerecorded invited and contributed talks and contributed posters. The virtual meeting space will remain live for ~30 days, allowing the international audience ample time to view content and interact with presenters.