The Biospecimen Science Group (BSG) develops and optimizes methods, protocols, and standard operating procedures for the long-term preservation of biospecimens and associated data to ensure sample stability and quality. The BSG provides the expertise for the cryogenic production of Standard Reference Materials® (SRMs) and control materials to support community-driven needs. Advice, training, and biorepository services are provided to other government agencies (federal and state), scientific organizations, and American industry. Research collaborations are maintained with the other partners of the Hollings Marine Laboratory in Charleston, SC, and with international organizations to establish best practices and advance biobanking technology and capabilities. Operations of the national cryogenic facility, the NIST Biorepository (formerly known as the Marine Environmental Specimen Bank), as well as the Cryogenic Reference Material Production Facility, are also managed and maintained by the BSG at NIST Charleston.