The Helios 650 NanoLab (HNL650) is a Focused Ion Beam Scanning Electron Microscope equipped with spectroscopic detectors to allow elemental and phase measurements to be performed at high spatial resolution. The HNL650 operates between 1 keV and 30 keV electron beam energy and 2 kV and 30 kV ion beam accelerating voltage. The HNL650 has an Elstar thermal (Schottky) field emission electron source and a Tomahawk ion column using a Ga+ liquid metal ion source. It is used for 3D chemical imaging of organic samples and automated hyperspectral analytical method development. The HNL650 is also equipped with retractable STEM detector, cryo stage, nano manipulator and multiple gas injection systems.