Hyphenated mass spectrometry techniques have been employed as one of the primary analytical tools for investigating the effects of ionizing radiation, chemical/biological carcinogens, and oxygen derived free radicals on the induction and subsequent repair of oxidatively-induced DNA damage (DNA lesions) in living systems. The National Institute of Standards and Technology has established a comprehensive research program focused on identifying mechanisms of DNA damage caused by commercially relevant engineered nanoparticles (NPs) using high resolution mass spectrometry for the quantification of oxidatively-induced DNA damage. We present results from a recently published study on the genotoxicity of National Institute of Standards and Technology (NIST) standard reference material (SRM) gold nanoparticles using isotope dilution liquid chromatography /mass spectrometry analysis.
Proceedings Title: Nanotech 2013
Conference Dates: May 12-16, 2013
Conference Location: Washington, DC
Pub Type: Conferences