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Size-exclusion chromatography of metal nanoparticles and quantum dots



Leena M. Pitkanen, Andre Striegel


This review presents an overview of size-exclusion chromatographic separation and characterization of noble metal nanoparticles (NPs) and quantum dots (QDs) over the past 25 years. The properties of NPs and QDs that originate from quantum and surface effects are size dependent; to investigate these properties, a separation technique such as size-exclusion chromatography (SEC) is often needed to obtain narrow distribution NP populations that are also separated from the unreacted starting materials. Information on the size distributions and optical properties of NPs have been obtained by coupling SEC to detection methods such as ultraviolet-visible and/or fluorescence spectroscopy. Problems associated with the sorption of NPs and QDs onto various SEC stationary phases, employing both aqueous and organic eluents, are also discussed here.
Trac-Trends in Analytical Chemistry


Size-exclusion chromatography, characterisation, metal nanoparticles, quantum dots


Pitkanen, L. and Striegel, A. (2016), Size-exclusion chromatography of metal nanoparticles and quantum dots, Trac-Trends in Analytical Chemistry, [online], (Accessed April 20, 2024)
Created April 7, 2016, Updated October 12, 2021