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Self-Assembled Monolayers of an Oligo(ethylene oxide) Disulfide and its Corresponding Thiol Assembled From Water: Characterization and Protein Resistance
Published
Author(s)
David J. Vanderah, Marlon L. Walker, Mark A. Rocco, Kenneth A. Rubinson
Abstract
The self-assembled monolayers (SAMs) of the ?-methyl oligo(ethylene oxide) disulfide [S(CH2CH2O)6CH3]2, [S(EO)6]2 {OEO disulfide}, on Au from 95 % ethanol and from water are described. Spectroscopic ellipsometry and reflection-absorption infrared spectroscopy data indicate the [S(EO)6]2 films are similar to the disordered films of HS(CH2CH2O)6CH3, (EO)6, and HS(CH2)3O(CH2CH2O)5CH3, C3EO5, at their protein adsorption minima. However, unlike the (EO)6 and C3EO5 thiols, the [S(EO)6]2 films are self-limiting in their surface packing density and sustain film thickness of 1.0 nm to 1.3 nm, corresponding to 50 % to 65 % coverage, over extended periods of time. As a result, OEO disulfides offer an attractive motif for the generation of thin, protein rejecting surfaces.
Ross, D.
, Walker, M.
, Rocco, M.
and Rubinson, K.
(2008),
Self-Assembled Monolayers of an Oligo(ethylene oxide) Disulfide and its Corresponding Thiol Assembled From Water: Characterization and Protein Resistance, Langmuir
(Accessed December 9, 2024)