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Displaying 1 - 11 of 11

Cotranscriptionally encoded RNA strand displacement circuits

March 23, 2022
Author(s)
Samuel Schaffter, Elizabeth Strychalski
Engineered molecular circuits that process information in biological systems could address emerging human health and biomanufacturing needs. However, such circuits can be difficult to rationally design and scale. DNA-based strand displacement reactions

Organizing genome engineering for the gigabase scale

February 9, 2021
Author(s)
Bryan A. Bartley, Jacob Beal, Jonathan R. Karr, Elizabeth Strychalski
Engineering an organism's entire genome enables large-scale changes in organization, function, and environmental interactions, with significant implications for industrial, medical, and environmental ap- plications broadly. Improvements to DNA synthesis

Cyberbiosecurity for biopharmaceutical products

February 8, 2021
Author(s)
Elizabeth Strychalski, Jennifer Mantla, Jayan Rammohan, Eugenia Romantseva, Reid D'Amico, Joel Welch, Leah R. Kauffman, James McCarthy, John E. Schiel, Jeffrey Baker, Kelley Rogers, Kelvin Lee

Genetic circuit design automation

April 1, 2016
Author(s)
Alec Nielsen, Bryan Der, Jonghyeon Shin, Prashant Vaidyanathan, Douglas Densmore, Vanya M. Paralanov, Elizabeth Strychalski, David J. Ross, Christopher Voigt
Computation can be performed in living cells using DNA-encoded circuits that process sensory information and control biological functions. Their construction is time-intensive, requiring manual part assembly and balancing of regulator expression. We

DNA ENTROPOPHORESIS: A BALANCE OF ENTROPY AND DIFFUSION IN COMPLEX NANOCONFINEMENT

October 3, 2011
Author(s)
Samuel Stavis, Jon Geist, Michael Gaitan, Laurie E. Locascio, Elizabeth Strychalski
Entropophoresis - motion caused by an entropy gradient - is a novel nanofluidic method to direct the self-transport of biopolymers that established a new paradigm of nanofluidic functionality with broad relevance to lab-on-a-chip technol-ogy. Here, the