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DNA ENTROPOPHORESIS: A BALANCE OF ENTROPY AND DIFFUSION IN COMPLEX NANOCONFINEMENT

Published

Author(s)

Samuel Stavis, Jon Geist, Michael Gaitan, Laurie E. Locascio, Elizabeth Strychalski

Abstract

Entropophoresis - motion caused by an entropy gradient - is a novel nanofluidic method to direct the self-transport of biopolymers that established a new paradigm of nanofluidic functionality with broad relevance to lab-on-a-chip technol-ogy. Here, the entropic effects on size variation of DNA molecules descending a nanofluidic staircase by entropophoresis are studied. A simple numerical model provides insight into the behavior of confined biopolymers - a controversial topic of basic importance in many lab-on-a-chip applications - and informs the rational design and self-operation of nanofluidic devices for future entropophoretic applications, such as the directed self-separation of biomolecular mixtures and directed self-patterning of biomolecular concentration gradients.
Proceedings Title
DNA ENTROPOPHORESIS: A BALANCE OF ENTROPY AND DIFFUSION IN COMPLEX NANOCONFINEMENT
Conference Dates
October 2-6, 2011
Conference Location
Seattle, WA, US
Conference Title
The 15th International Conference on Miniaturized Systems for Chemistry and Life sciences

Keywords

Nanofluidics, DNA, Entropophoresis, Ideal chain, Polymer

Citation

Stavis, S. , Geist, J. , Gaitan, M. , Locascio, L. and Strychalski, E. (2011), DNA ENTROPOPHORESIS: A BALANCE OF ENTROPY AND DIFFUSION IN COMPLEX NANOCONFINEMENT, DNA ENTROPOPHORESIS: A BALANCE OF ENTROPY AND DIFFUSION IN COMPLEX NANOCONFINEMENT, Seattle, WA, US (Accessed July 6, 2022)
Created October 2, 2011, Updated October 12, 2021