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Search Publications by: Aaron M. Goldfain (Fed)

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Displaying 1 - 11 of 11

Advancing evanescent light scattering microscopy for single-particle characterization of gene delivery nanoparticles

March 4, 2026
Author(s)
Jagat Budhathoki, Gregory Cooksey, Matthew DiSalvo, Thomas Germer, Peter Bajcsy, Edward Kwee, Aaron Goldfain, Alexander Peterson
Precise and reproducible single-nanoparticle characterization is essential for advancing gene therapy, where viral vectors encapsulating therapeutic genes must be evaluated under formulation-relevant conditions. We present a label-free optical platform

Demonstration, validation, and application of hyperspectral microscopy for the collection of cyanobacterial spectral signatures

February 24, 2026
Author(s)
Natalie C. Hall, Adam Mumford, Aaron Goldfain, David Allen, Terry slonecker, Alisa Shtabnoy
Cyanobacterial and other algal blooms are an environmental concern in waterbodies worldwide. While these blooms are a nuisance for recreational activities, they can also be harmful to human and wildlife health when the algae produce and release toxins

Measuring the size of oil droplets in a flow cytometer using Mie Resonances

January 21, 2025
Author(s)
Richard E. Cavicchi, Dean Ripple, Joshua Welsh, Jerilyn Izac, Alexander Peterson, Aaron Goldfain, Wyatt Vreeland
An emulsion of silicone oil droplets in aqueous buffer produces a distinctive series of peaks or resonances in the side scatter histogram in a flow cytometer. As many as 12 peaks are observed in the violet-side scatter channel at 405 nm, with half that

Spatial frequency domain Mueller matrix imaging

December 14, 2022
Author(s)
Joseph Chue-Sang, Maritoni Litorja, Aaron Goldfain, Thomas A. Germer
Significance: Mueller matrix polarimetry (MMP) and spatial frequency domain imaging (SFDI) are wide-field optical imaging modalities that differentiate tissue primarily by structure alignment and photon transport coefficient, respectively. Because these

Polydimethylsiloxane tissue-mimicking phantoms with tunable optical properties

July 1, 2022
Author(s)
Aaron Goldfain, Paul Lemaillet, David W. Allen, Kimberly Briggman, Jeeseong C. Hwang
We report on techniques to manufacture and characterize solid tissue-mimicking phantoms of polydimethylsiloxane (PDMS) polymers. Tunability of the absorption (a()) and reduced scattering spectra (s'()) in the wavelength range of 500 nm to 850 nm is

Spatial frequency domain Mueller matrix imaging

April 22, 2021
Author(s)
Joseph Chue-Sang, Aaron Goldfain, Jeeseong C. Hwang, Thomas A. Germer
We combine Mueller matrix polarimetry (MMP) with spatial frequency domain imaging (SFDI) to create a technique that is sensitive to near-surface material anisotropy. We demonstrate this imaging modality with scattering and absorbing phantoms and with a

Dual-comb photoacoustic spectroscopy

June 19, 2020
Author(s)
Jacob T. Friedlein, Esther Baumann, Kimberly Briggman, Gabriel M. Colacion, Fabrizio R. Giorgetta, Daniel I. Herman, Nathan R. Newbury, Jeeseong Hwang, Ian R. Coddington, Kevin C. Cossel, Gabriel Ycas, Christopher Yung, Eli V. Hoenig, Edgar F. Perez, Aaron Goldfain
Spectrally-resolved photoacoustic imaging is a promising technique for label-free imaging in optically scattering materials. However, this technique often requires acquisition of a separate image at each wavelength of interest. This reduces imaging speeds
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