November 26, 2021
Author(s)
Diana Gomes, Susana C. Marujo Teixeira, Juscelino Leao, Vladimir Razinkov, Wei Qi, Miguel Rodrigues, Christopher Roberts
Biopharmaceutical formulations may be compromised by freezing, which has been attributed to protein conformational changes at a low temperature, and adsorption to ice−liquid interfaces. However, direct measurements of unfolding/conformational changes in