Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

High Pressure Cell for Bio-SANS Studies under Sub-Zero Temperatures or Heat Denaturing Conditions



Susana Cristina Marujo Teixeira, Juscelino Leao, Cedric Victor Lucien Gagnon, M. A. McHugh


The second biennial International Society for Sample Environment (ISSE) school included training on high pressure (HP) cells for Soft Matter studies. Neutron research centers are responding to a growing need for HP experimental data, relevant to broad range of applications in bioscience, biotechnology and others. The need to disseminate existing designs and operating protocols, to support concerted efforts towards the advancement of sample environment instrumentation across research centers, was highlighted throughout discussions during the ISSE school. The liquid insertion pressure system for SANS (LIPSS), currently used at the NIST Center for Neutron Research for solutions of biological macromolecules, is described here. Emphasis is placed on the context of subzero temperature studies and the design challenges.
Journal of Neutron Research


High pressure, subzero temperature, Small-Angle Neutron Scattering, Cold Denaturation, Proteins


, S. , Leao, J. , Lucien, C. and , M. (2018), High Pressure Cell for Bio-SANS Studies under Sub-Zero Temperatures or Heat Denaturing Conditions, Journal of Neutron Research, [online], (Accessed April 17, 2024)
Created June 28, 2018, Updated November 9, 2018