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Search Publications by: Gregory A Cooksey (Fed)

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Displaying 26 - 49 of 49

Integrated Optical Waveguides for in situ Microflow Measurements

October 15, 2017
Author(s)
James R. Hands, Gregory A. Cooksey
The need for quantitative microscale chemical and biological experiments has resulted in the increasing utilization of microfluidics with integrated sensors, allowing such architectures to synergistically enhance function and performance [1]. This work

Design, sensitivity analysis, and testing of a Caenorhabditis elegans nanoecotoxicity assay

August 11, 2016
Author(s)
Shannon Hanna, Gregory A. Cooksey, Bryant C. Nelson, John T. Elliott, Elijah J. Petersen
Increasing production and usage of engineered nanomaterials (ENMs) has generated widespread interest in measuring their environmental and human health effects. However, the lack of standardized methods for these measurements has often led to contradictory

Performance Benchmarking and Intensity Calibration of a Widefield Fluorescence Microscope Using Fluorescent Glass

August 11, 2014
Author(s)
Michael W. Halter, Elianna Bier, Paul C. DeRose, Gregory A. Cooksey, Steven J. Choquette, Anne L. Plant, John T. Elliott
Widefield fluorescence microscopy is a highly used tool for visually assessing biological samples and for quantifying cell responses. Despite its widespread use in high content analysis and other screening applications, few published methods exist for

A robust diffusion-based gradient generator for dynamic cell assays.

January 1, 2012
Author(s)
Francisco J. Atencia, Gregory A. Cooksey, Laurie E. Locascio
This manuscript describes a new method to generate purely diffusive chemical gradients that can be modified in time. The device is simple in its design and easy to use, which makes it amenable to study biological processes that involve static or dynamic

Reproducibility and Robustness of a Real-Time Microfluidic Cell Toxicity Assay

May 15, 2011
Author(s)
Gregory A. Cooksey, John T. Elliott, Anne L. Plant
Numerous opportunities exist to apply microfluidic technology to high-throughput and high-content cell-based assays. However, maximizing the value of these assays for drug discovery, screening or toxicity evaluation, for example, will require validation of

Magnetic connectors for microfluidic applications

January 1, 2010
Author(s)
Francisco J. Atencia, Gregory A. Cooksey, Andreas Jahn, Justin M. Zook, Wyatt N. Vreeland, Laurie E. Locascio
We present a new type of connector based on a simple idea: using a ring magnet on one side of the microfluidic chip and a disc magnet on the other side to provide the interfacial force necessary to provide a sealed connection between tubing or needles and

A vacuum manifold for rapid world-to-chip connectivity of complex PDMS microdevices

January 1, 2009
Author(s)
Gregory A. Cooksey, Anne L. Plant, Francisco J. Atencia
The lack of simple interfaces for microfluidic devices with a large number of inlets significantly limits production and utilization of these devices. In this paper, we describe the fabrication of a reusable manifold that provides rapid world-to-chip