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Search Publications by: Yun Liu (Fed)

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Displaying 1 - 25 of 84

Dual-Modality Poly-^dL-Histidine Nanoparticles to Deliver Peptide Nucleic Acids and Paclitaxel for In Vivo Cancer Therapy

September 29, 2021
Author(s)
Aniket Wahane, Shipra Malik, Kuo-Chih Shih, Ravinder R. Gaddam, Chaohao Chen, Yun Liu, Mu-Ping Neih, Ajit Vikram, Raman Bahal
Cationic polymeric nanoformulations have been explored to increase the transfection efficiency of small molecules and nucleic acid-based drugs. However, excess of positive charge often leads to severe cell and tissue-based toxicity that restrict the

Small-Angle Neutron Scattering Characterization of SrCl 2 -ENG Composite for Thermochemical Heat Storage

July 28, 2021
Author(s)
Anastasiia Karabanova, Kenneth D. Knudsen, Perizat Berdiyeva, Leide P. Cavalcanti, Yun Liu, Michel van der Pal, Stefano Deledda, Didier Blanchard
This work presents an in-situ nanoscale structural characterization of the composite material SrCl2-Expanded Natural Graphite (ENG) during ammonia absorption and desorption, using small angle neutron scattering (SANS) together with X-ray powder diffraction

Preservative Induced Polysorbate 80 Micelle Aggregation

June 1, 2021
Author(s)
Peter H. Gilbert, Zhenhuan Zhang, Ken K. Qian, David P. Allen, Norman J. Wagner, Yun Liu
Small angle neutron scattering (SANS) studies of a model pharmaceutical formulation reveal how formulation stability depends on the compatibility of individual components. Solutions of two common protein formulation excipients, polysorbate 80 (PS80), a

Demonstration of Small-Angle Neutron Scattering Measurements with a Nested Neutron-Focusing Supermirror Assembly

April 21, 2021
Author(s)
Huarui Wu, Zhiyuan Wang, Yao Zhang, Wenbo Mo, Pulin Bai, Kun Song, Zhong Zhang, Zhanshan Wang, Daniel S. Hussey, Yun Liu, Zhe Wang, Xuewu Wang
Neutron-focusing mirrors with both a nested structure and supermirror coatings enable a large collecting area, and consequently a large neutron current gain for mirror-based instruments. A nested neutron-focusing supermirror assembly has been fabricated

Cluster Morphology of Colloidal Systems with Competing Interactions

April 15, 2021
Author(s)
Nestor E. Valadez-Perez, Yun Liu, Ramon Castaneda-Priego
Reversible aggregation of purely short-ranged attractive colloidal particles leads to the formation of clusters with a fractal dimension that only depends on the second virial coefficient. The addition of a long-ranged repulsion to the potential modifies

Intermediate Scattering Functions of a Rigid Body Monoclonal Antibody Protein in Solution Studied by Dissipative Particle Dynamic Simulation

April 8, 2021
Author(s)
Yanqin Zhai, Nicos Martys, William L. George, Joseph E. Curtis, Jannatun Nayem, Y. Z, Yun Liu
In the past decade, there is increased research interest in studying internal motions of flexible proteins in solution using Neutron Spin Echo (NSE) as NSE can simultaneously probe the dynamics at the length and time scale comparable to protein domain

Molecular View on Mechanical Reinforcement in Polymer Nanocomposites

March 16, 2021
Author(s)
Ruikun Sun, Matthew Melton, Niloofar Safaie, Jr. Ferrier, Shiwang Cheng, Yun Liu, Xiaobing Zuo, Yangyang Wang
The microscopic origin of mechanical enhancement in polymer nanocomposites (PNCs) is investigated through the combination of rheology and small-angle neutron scattering. It is shown that in the absence of an extensive particle network, the molecular

Controlling Bicontinuous Structures through Solvent Segregation Driven Gel

February 16, 2021
Author(s)
Yuyin Xi, Juscelino Leao, Qiang Ye, Ronald S. Lankone, Li Piin Sung, Yun Liu
The past decade has seen increased research interests in studying bicontinuous structures formed by the colloidal self-assembly due to their many useful applications. A new type of colloidal gel, solvent segregation driven gel (SeedGel), has been recently

Adsorption of Non-Ionic Surfactant and Monoclonal Antibody on Siliconized Surface Studied by Neutron Reflectometry

February 15, 2021
Author(s)
Zhenhuan Zhang, Ann M. Woys, Kunlun Hong, Christoph Grapentin, Tarik A. Khan, Isidro E. Zarraga, Norman J. Wagner, Yun Liu
The adsorption of monoclonal antibodies (mAbs) on hydrophobic surfaces is known to cause protein aggregation and degradation. Therefore, surfactants, such as Poloxamer 188, are widely used in therapeutic formulations to stabilize mAbs and protect mAbs from

Alignment of Worm-like Micelles at Intermediate and High Shear Rates

February 1, 2020
Author(s)
Brisa Arenas-Gomez, Cristina Garza, Yun Liu, Rolando Castillo
Hypothesis. Rheology combined with Small Angle Neutron Scattering (Rheo-SANS) can determine the local structural order in Worm-like Micelle (WLM) solutions, when the shear rate increases beyond the ending of the gradient shear banding, where the micellar

Dynamic Equivalence between Soft Star Polymers and Hard Spheres

November 19, 2019
Author(s)
Zhe Wang, Antonio Faraone, Panchao Yin, Lionel Porcar, Yun Liu, Changwoo Do, Kunlun Hong, Wei-Ren Chen
We measure a series of star polymer dispersions to study the dynamics of soft colloidal liquids. We find that as the concentration increases, the slowing of the long-time self-diffusivity of the star polymer, normalized by the short-time self-diffusivity

Orientational Distribution Function of Aligned Elongated Molecules and Particulates Determined from Their Scattering Signature

October 15, 2019
Author(s)
Guan-Rong Huang, Yangyang Wang, Changwoo Do, Yuya Shinohara, Takeshi Egami, Lionel Porcar, Yun Liu, Wei-Ren Chen
We present a strategy for quantitatively evaluating the field-induced alignment of non-spherical particles using small angle scattering techniques. The orientational distribution function (ODF) is determined from the anisotropic scattering intensity via

Quantification of a PbCl x Shell on the Surface of PbS Nanocrystals

August 5, 2019
Author(s)
Samuel W. Winslow, Yun Liu, James W. Swan, William A. Tisdale
Differences between the properties of PbS nanocrystals prepared using a large excess of PbCl2 and those prepared using other Pb sources have led to speculation that a thin PbClx shell may be present on the surface of PbCl2-derived PbS nanocrystals. However

Characterization of Colloidal Nanocrystal Surface Structure using Small Angle Neutron Scattering and Efficient Bayesian Parameter Estimation

June 28, 2019
Author(s)
Samuel W. Winslow, Wenbi Shcherbakov-Wu, Yun Liu, William A. Tisdale, James W. Swan
Complete structural characterization of colloidal nanocrystals is challenging due to rapid variation in the electronic, vibrational, and elemental properties across the nanocrystal surface. while electron microscopy and X-ray scattering techniques can