Publications

Displaying 1 - 15 of 15

Increasing the Coverage of a Mass Spectral Library of Milk Oligosaccharides Using a Hybrid- Search-Based Bootstrapping Method and Milks from a Wide Variety of Mammals

July 8, 2020

Author(s)

Concepcion A. Remoroza, Tytus D. Mak, Yuri A. Mirokhin, Sergey L. Sheetlin, Xiaoyu Yang, Stephen E. Stein, Power L. Michael, San Andres V. Joice, Yuxue Liang

This study significantly expands both the scope and method of identification for construction of a previously reported tandem mass spectral library of 74 human

Mass Spectral Library of Acylcarnitines Derived from Human Urine

April 8, 2020

Author(s)

Xinjian Yan, Sanford Markey, Ramesh Marupaka, Qian Dong, Brian T. Cooper, Yuri Mirokhin, William E. Wallace, Stephen Stein

We describe the creation of a mass spectral library of acylcarnitines and conjugated acylcarnitines from the LC–MS/MS analysis of six NIST urine reference

Sensitive Method for the Confident Identification of Genetically Variant Peptides in Human Hair

October 31, 2019

Author(s)

Zheng Zhang, Meghan C. Burke, William E. Wallace, Yuxue Liang, Sergey L. Sheetlin, Yuri A. Mirokhin, Dmitrii V. Tchekhovskoi, Stephen E. Stein

Recent reports have demonstrated that genetically variant peptides (GVPs) derived from human hair shaft proteins can be used to differentiate individuals of

Hybrid search: a method for identifying metabolites absent from tandem mass spectrometry libraries

October 10, 2019

Author(s)

Brian T. Cooper, Xinjian Yan, Yamil Simon, Dmitrii V. Tchekhovskoi, Yuri A. Mirokhin, Stephen E. Stein

Metabolomics has a critical need for better tools for mass spectral identification. Common metabolites may be identified by searching libraries of tandem mass

Mass Spectrometry Fingerprints of Small-Molecule Metabolites in Biofluids. Building a Spectral Library of Recurrent Spectra for Urine Analysis.

August 19, 2019

Author(s)

Yamil Simon, Ramesh Marupaka, Xinjian Yan, Yuxue Liang, Kelly H. Telu, Yuri A. Mirokhin, Stephen E. Stein

A large fraction of ions observed in electrospray liquid chromatography-mass spectrometry (LC-MS) experiments of biological samples remain unidentified. One the

Mass Spectrometry Fingerprints of Small-Molecule Metabolites in Biofluids. Building a Spectral Library of Recurrent Spectra for Urine Analysis

August 19, 2019

Author(s)

Yamil Simon, Ramesh Marupaka, Xinjian Yan, Yuxue Liang, Kelly H. Telu, Yuri A. Mirokhin

A large fraction of ions observed in electrospray liquid chromatography-mass spectrometry (LC- MS) experiments of biological samples remain unidentified. One

False Discovery Rate Estimation for Hybrid Mass Spectral Library Search Identifications in Bottom-up Proteomics

July 31, 2019

Author(s)

Meghan C. Burke, Zheng Zhang, Yuri A. Mirokhin, Dmitrii V. Tchekhovskoi, Yuxue Liang, Stephen E. Stein

We present a method for FDR estimation of mass spectral library search identifications made by a recently developed method for peptide identification, the

Creating a Mass Spectral Reference Library for Oligosaccharides in Milk

July 3, 2018

Author(s)

Concepcion A. Remoroza, Tytus D. Mak, M. L. De Leoz, Yuri A. Mirokhin, Stephen E. Stein

We report the development and availability of a mass spectral reference library for oligosaccharides in human milk. This represents a new variety of spectral

The NISTmAb Tryptic Peptide Spectral Library for Monoclonal Antibody Characterization

February 9, 2018

Author(s)

Qian Dong, Yuxue Liang, Xinjian Yan, Sanford P. Markey, Yuri A. Mirokhin, Dmitrii V. Tchekhovskoi, Tallat H. Bukhari, Stephen E. Stein

We describe the creation of a mass spectral library composed of all identifiable spectra derived from the tryptic digest of a therapeutic monoclonal antibody

Reverse and Random Decoy Methods for False Discovery Rate Estimation in High Mass Accuracy Peptide Spectral Library Searches

February 2, 2018

Author(s)

Zheng Zhang, Meghan C. Burke, Yuri A. Mirokhin, Dmitrii V. Tchekhovskoi, Sanford P. Markey, Wen Yu, Raghothama Chaerkady, Sonja Hess, Stephen E. Stein

Spectral library searching (SLS) is an attractive alternative to sequence database searching (SDS) for peptide identification due to its speed, sensitivity, and

The Hybrid Search: A Mass Spectral Library Search Method for Discovery of Modifications in Proteomics

April 3, 2017

Author(s)

Meghan C. Burke, Yuri A. Mirokhin, Dmitrii V. Tchekhovskoi, Sanford P. Markey, Stephen E. Stein, Jenny Heidbrink Thompson, Christopher Larkin

We present a mass spectral library based method to identify tandem mass spectra of peptides that contain unanticipated modifications and amino acid variants. We

Interconversion of Peptide Mass Spectral Libraries Derivatized with iTRAQ or TMT Labels

July 7, 2016

Author(s)

Zheng Zhang, Xiaoyu Yang, Yuri A. Mirokhin, Dmitrii V. Tchekhovskoi, Weihua Ji, Sanford P. Markey, Pedatsur Neta, Bowen A. Michael, Stephen E. Stein

Derivatizing peptides with isobaric tags such as iTRAQ and TMT is widely employed in proteomics due to their ability to multiplex quantitative measurements. We

A Description of the Clinical Proteomics Tumor Analysis Consortium (CPTAC) Common Data Analysis Pipeline

February 10, 2016

Author(s)

Jeri S. Roth, Paul A. Rudnick, Sanford P. Markey, Yuri A. Mirokhin, Xinjian Yan, Dmitrii V. Tchekhovskoi, Stephen E. Stein, Nathan J. Edwards, Ratna R. Thangudu, Karen A. Ketchum, Christopher R. Kinsinger, Mehdi Mesri, Henry Rodriguez

The Clinical Proteomic Tumor Analysis Consortium (CPTAC) has produced large proteomics datasets from the mass spectrometric interrogation of tumor samples

Creation of Libraries of Recurring Mass Spectra from Large Data Sets assisted by a Dual-Column Workflow

September 18, 2014

Author(s)

William G. Mallard, Stephen E. Stein, Halket M. John, Yuri A. Mirokhin, Nirina Rabe Andriamaharavo

An analytical methodology has been developed for extracting recurrent unidentified spectra (RUS) from large GC/MS data sets. Spectra were first extracted from

Tandem Mass Spectral Libraries of Peptides in Digests of Individual Proteins: Human Serum Albumin

June 2, 2014

Author(s)

Qian Dong, Xinjian Yan, Lisa E. Kilpatrick, Yuxue Liang, Yuri A. Mirokhin, Jeri S. Roth, Stephen E. Stein

This work presents a method for creating a mass spectral library containing tandem spectra identifiable peptide ions in the tryptic digestion of a single

Advanced communications
-Optical communications
-Quantum communications
-Wireless (RF)
Bioscience
-Biomaterials
-Biomolecular characterization
-Bioprocessing
-Cell biology
-Engineering / synthetic biology
-Genomics
-Glycomics
-Metabolomics
-Microbial measurements
-Proteomics
Buildings and Construction
-Building codes and standards
-Building control systems
-Building damage and repair
-Building economics
-Building materials
-Heating, ventilation and air conditioning equipment
-Indoor air quality
-Resilient buildings
-Structural engineering
-Sustainable buildings
Chemistry
-Analytical chemistry
-Chemical engineering and processing
-Chemical thermodynamics and chemical properties
-Molecular characterization
-Theoretical chemistry and modeling
-Thermochemical properties
Electronics
-Electromagnetics
-Flexible electronics
-Magnetoelectronics
-Optoelectronics
-Organic electronics
-Semiconductors
-Sensors
-Superconducting electronics
Energy
-Alternative energy
-Conventional energy
-Electric power / smart grid
-Energy efficiency
-Fuels
-Sustainability
Environment
-Air / water / soil quality
-Climate
-Environmental health
-Greenhouse gas measurements
-Marine science
Fire
-Emergency building evacuation
-Fire detection
-Fire dynamics and science
-Fire fighting
-Fire modeling
-Fire risk reduction
-Materials flammability
-Structural fire resistance
-Wildland urban interface fire
Forensic Science
-Ballistics
-Digital evidence
-DNA and biological evidence
-Drugs and toxicology
-Fingerprints and pattern evidence
-Trace evidence
Health
-Clinical diagnostics
-Dentistry
-Food and nutrition
-Medical imaging
-Pharmaceuticals
-Precision medicine
-Regenerative medicine
Information technology
-Artificial intelligence
-Biometrics
-Cloud computing and virtualization
-Complex systems
-Computational science
-Conformance testing
-Cyber-physical systems
--Smart cities
-Cybersecurity
--Configuration and vulnerability management
--Cryptography
--Cybersecurity education and workforce development
--Risk management
-Data and informatics
--Human language technology
--Information retrieval
--Natural language processing
-Data enry
-Federal information standards (FIPS)
-Health IT
-Identity and access management
-Internet of Things (IoT)
-Interoperability testing
-Mobile
-Networking
--Mobile and wireless networking
--Network management and monitoring
--Network modeling and analysis
--Network security and robustness
--Network test and measurement
--Next generation networks
--Protocol design and standardization
--Software defined and virtual networks
-Privacy
-Software research
--Software assurance
--Software performance
--Software testing
-Usability and human factors
--Accessibility
-Video analytics
-Visualization research
-Voting systems
Infrastructure
Manufacturing
-Additive manufacturing
-Biomanufacturing
-Factory communications
-Factory operations planning and control
-Interoperability in manufacturing
-Machining
-Manufacturing systems design and analysis
-Monitoring, diagnostics and prognostics
-Process improvement
-Process measurement and control
-Product data
-Quality assurance
-Robotics in manufacturing
--Agility and adaptability
--Collaborative robots
--Dexterous grasping
--Industrial autonomous vehicles
--Mobile manipulators
--Navigation / actuation / control
--Sensing and perception
-Supply chain
-Sustainable manufacturing
-Systems engineering
-Systems integration
-Technology commercialization
Materials
-Ceramics
-Composites
-Concrete / cement
-Materials characterization
--Composition and structure
--Magnetic properties
--Mechanical properties
--Thermal properties
-Metals
-Modeling and computational material science
-Polymers
-Superconductors
Mathematics and Statistics
-Experiment design
-Image and signal processing
-Mathematical knowledge management
-Modeling and simulation research
-Numerical methods and software
-Statistical analysis
-Uncertainty quantification
Metrology
-Acoustic / vibration metrology
-Amount of substance
-Dimensional metrology
-Electrical / electromagnetic metrology
-Flow metrology and rheology
-Force metrology
-Humidity metrology
-Ionizing radiation metrology
-Mass metrology
-Metric
-Optical / photometry / laser metrology
-Pressure and vacuum metrology
-Thermometry metrology
-Time and frequency metrology
-Weights and measures
Nanotechnology
-Nanobiotechnology
-Nanochemistry
-Nanoelectronics
-Nanofabrication / manufacturing
--Lithography
--Self-assembly
-Nanofluidics
-Nanomagnetics
-Nanomaterials
-Nanomechanics
-Nanometrology
-Nanophotonics
-Nanophysics
-Nanoplasmonics
Neutron research
Performance excellence
-Assessment tools and services
-Baldrige award
-Baldrige examiners
-Baldrige Framework and Criteria
-Best practices
-Leadership development
Physics
-Atomic / molecular / quantum
-Biological physics
-Condensed matter
-Electron physics
-Magnetics
-Nuclear physics
-Optical physics
-Quantum information science
-Radiation
-Spectroscopy
-Thermodynamics
-Time and frequency
Public safety
-Chemical / Biological / Radiological / Nuclear / Explosives (CBRNE)
-First responder preparedness
-Law enforcement
-Physical security
-Public safety communications research
-Response robots
--Aerial
--Aquatic and underwater
--Ground
Resilience
-Community resilience
-Disaster and failure studies
-Earthquake risk reduction
-Resilient materials
-Windstorm impact reduction
Standards
-Accreditation
-Calibration services
-Conformity assessment
-Documentary standards
-Frameworks
-Reference data
-Reference instruments
-Reference materials
-Standards education
Transportation
-Aerospace
-Automotive
-Rail

Search Publications by Yuri Mirokhin