Publications

Displaying 1 - 25 of 62

A MULTIDIMENSIONAL LANDSCAPE MODEL FOR DETERMINING CELLULAR NETWORK THERMODYNAMICS

March 11, 2020

Author(s)

Joseph B. Hubbard, Michael W. Halter, Anne L. Plant

The distribution of phenotypic responses within an isogenic population of cells reflects the thermodynamics of a stationary state that results from coordinated intracellular reactions. The distribution of phenotypes is the result of both deterministic and

Extracting Two Parameters From a P2 Orientation Distribution

February 19, 2017

Author(s)

Curtis Meuse, Joseph B. Hubbard

Individual molecules are seldom identical. This poses a problem for optical spectroscopy. For instance, if molecular property distributions are not characterized, differences in the distribution of molecular properties between sample and standards are

Modeling Diffusive Ionic Transport in Concentrated Alkaline Cementitious Pore Solutions at 25 C: Comparison to Published Binary Salt Data

February 19, 2017

Author(s)

Kenneth A. Snyder, Joseph B. Hubbard, J Marchand

The applicability of a Nernst-Planck equation to characterizing diffusive transport in concentrated electrolytes typically found in cementitious systems is investigated using published experimental data for the collective diffusion coefficient of binary

Nonparametric Estimates of Drift and Diffusion Profiles via Fokker-Planck Algebra

October 13, 2014

Author(s)

Steven P. Lund, Michael W. Halter, Joseph B. Hubbard

Diffusion processes superimposed upon deterministic motion play a key role in understanding and controlling the transport of matter, energy, momentum, and even information in physics, chemistry, material science, biology, and communications technology

Characterizing the Hemming Performance of Automotive Aluminum Alloys With High-Resolution Topographic Imaging

April 1, 2014

Author(s)

Mark R. Stoudt, Joseph B. Hubbard, John E. Carsley, Susan E. Hartfield-W?nsch

The hemming performances of two AA6xxx series aluminum automotive closure panel alloys were evaluated, with and without a 10 % tensile pre-strain, in a simulated three-point bend test that bent samples to a 180 ° angle. The apexes of the bent specimens

Characterizing the Hemming Performance of Automotive Aluminum Alloys with High-Resolution Topographic Imaging

April 1, 2014

Author(s)

Mark R. Stoudt, Joseph B. Hubbard, John E. Carsley, Susan E. Hartfield-W?nsch

A high-resolution quantitative surface analysis technique was used to evaluate the surface characteristics of two AA6xxx series aluminum automotive closure panel alloys that were bent to a 180 ° angle in a simulated hemming test. Topographic data were

Boltzmann's H-Function and Diffusion Processes

May 15, 2013

Author(s)

Steven P. Lund, Joseph B. Hubbard, Michael W. Halter

There exists a generalization of Boltzmann's $H$-function that allows for non-uniformly populated stationary states which may exist far from thermodynamic equilibrium. Here we describe a method for obtaining a generalized or collective diffusion

Predicting rates of cell state change due to stochastic fluctuations using a data-driven landscape model

November 20, 2012

Author(s)

Daniel R. Sisan, Michael Halter, Joseph B. Hubbard, Anne L. Plant

In this paper, we develop a potential landscape approach to quantitatively describe experimental data from a fibroblast cell line that expresses GFP under the control of the promoter for tenascin-C. Time lapse live cell microscopy provides data about short

On the Relationship Between Deformation-Induced Surface Roughness and Plastic Strain in AA5052 Is it Really Linear?

August 1, 2011

Author(s)

Mark R. Stoudt, Joseph B. Hubbard, Stefan D. Leigh

Three different heat treatments of aluminum alloy AA5052 were subjected to various levels of uniaxial plastic strain. The resulting surface topographies were then evaluated using scanning laser confocal microscopy (SLCM) and stylus profilometry

Weibull Regression Analysis of Filtered Surface Roughness Data and Strain Prediction in a Metallic Alloy

July 1, 2011

Author(s)

Joseph B. Hubbard, Mark R. Stoudt, Antonio Possolo

We fit a two-parameter Weibull regression (WR) model by maximum likelihood estimation (MLE) to filtered surface roughness data. These data were acquired by scanning confocal laser microscopy performed on aluminum alloy AA5754-O surfaces that were subjected

The Fundamental Relationships Between Deformation-Induced Surface Roughness, Critical Strain Localization, and Failure in AA5754-O

September 1, 2009

Author(s)

Mark R. Stoudt, Joseph B. Hubbard

The apparent clustering observed in localized strain maps constructed from deformation-induced surface topographies generated in AA5754-O by three in-plane deformation modes were analyzed by two different methods. One used a conventional two-point

A Study of the Fundamental Relationships Between Deformation-Induced Surface Roughness and Strain Localization in AA5754

July 1, 2009

Author(s)

Mark R. Stoudt, Joseph B. Hubbard, Mark A. Iadicola, Stephen W. Banovic

This research characterizes deformation-induced surface roughness produced by 3, in plane, proportional strain modes to determine the microstructural conditions that promote strain localization in AA5754-O aluminum alloy sheet. Integrating high-resolution

Cell volume distributions reveal cell growth rates and division times

March 7, 2009

Author(s)

Michael W. Halter, John T. Elliott, Joseph B. Hubbard, Alessandro Tona, Anne L. Plant

A population of cells in culture displays a range of phenotypic responses, even when those cells are derived from a single cell and are exposed to a homogeneous environment. Phenotypic variability can have a number of sources, including the variable rates

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