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Bioscience

Bioeconomy

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Displaying 1 - 10 of 10

Beyond Sequence Similarity: The Case for Function-Based Screening of Nucleic Acid Synthesis

May 13, 2026
Author(s)
Gary Able, Tessa Alexanian, Jacob Beal, James Diggans, Kevin Flyangolts, Gene D. Godbold, Eric Horvitz, Bin Hu, Caitlin Jagla, Rassin Lababidi, Brittany Rife Magalis, Sebastian Rivera, Bruce Wittmann, Samuel Forry, David Ross, Sheng Lin-Gibson, Samuel Curtis
Synthetic nucleic acids are a key input to modern biotechnology, yet they represent dual-use materials that require robust screening to mitigate biosecurity risks. The prevailing screening paradigm identifies sequences of concern (SoCs) through sequence

A mathematical framework to correct for compositionality in microbiome datasets

January 6, 2026
Author(s)
Samuel Forry, Stephanie Servetas, Jason Kralj, Monique Hunter, Jennifer Dootz
The increasing use of metagenomic sequencing (MGS) for microbiome analysis has significantly advanced our understanding of microbial communities and their roles in various biological processes, including human health, environmental cycling, and disease

National Institute of Standards and Technology Environmental Scan 2023: Societal and Technology Landscape to Inform Science and Technology Research

August 23, 2023
Author(s)
Ashley Russell, Kerrianne Buchanan, David Griffith, Heather Evans, Dimitrios Meritis, Lisa Ng, Anna Sberegaeva, Michelle Stephens
The 2023 National Institute of Standards and Technology Environmental Scan provides an analysis of key external factors that could impact NIST and the fulfillment of its mission in coming years. The analyses were conducted through three separate lenses

Toward a common standard for data and specimen provenance in life sciences

April 18, 2023
Author(s)
Rudolf Wittner, Petr Holub, Cecilia Mascia, Francesca Frexia, Heimo Muller, Markus Plass, Clare M Allocca, Fay Betsou, Tony Burdett, Ibon Cancio, Adriane Chapman, Martin Chapman, Melanie Courtot, Vasa Curcin, Johann Eder, Mark Elliot, Katrina Exter, Carole Goble, Martin Golebiewski, Bron Kisler, Andreas Kremer, Simone Leo, Sheng Lin-Gibson, Anna Marsano, Marco Mattavelli, Josh Moore, Hiroki NAKAE, Isabelle PERSEIL, Ayat Salman, James Sluka, Stian Soiland-Reyes, Caterina Strambio De Castillia, michael sussman, Jason Swedlow, Kurt Zatloukal, Joerg Geiger
Open and practical exchange, dissemination, and reuse of specimens and data have become a fundamental requirement for life sciences research. The quality of the data obtained and thus the findings and knowledge derived is thus significantly influenced by

Effects of DNA Template Preparation on Variability in Cell-Free Protein Production

August 13, 2022
Author(s)
Eugenia Romantseva, Nina Alperovich, David Ross, Steven Lund, Elizabeth Strychalski
DNA templates for protein expression remain an unexplored source of variability in the performance of cell-free expression (CFE) systems for protein production. To characterize this variability, we investigated the effects of two common DNA extraction

THE GUT MICROBIOME AND XENOBIOTICS: IDENTIFYING KNOWLEDGE GAPS

July 1, 2020
Author(s)
Vicki L. Sutherland, Charlene A. McQueen, donna Mendrick, donna gulezian, Carl Cerniglia, Steven Foley, Samuel Forry, Sangeeta Khare, Xue Liang, Jose E. Manautou, Donald Tweedie, howard young, Alexander Aleksenkyo, frank burns, Rod Dietert, Katherine Karberg, alan wilson, connie chen
There is an increasing awareness that the gut microbiome plays a critical role in human health and disease, but mechanistic insights are often lacking. In June 2018, the Health and Environmental Sciences Institute (HESI) held a workshop, "The Gut

EcoFAB: Advancing microbiome science through standardized fabricated ecosystems

June 21, 2019
Author(s)
Karsten Zengler, Kirsten Hofmockel, Scott Behie, Hans Bernstein, James Brown, Jos? Dinneny, Sheri Floge, Samuel Forry, Matthias Hess, Scott Jackson, Stephen Lindemann, Jennifer Pett-Ridge, Elizabeth Shank, Ophelia Venturelli, Matthew Wallenstein, Nitin Baliga, Christer Jansson, Trent Northen
Microbiome science is arguably the fastest-advancing research field in biology today. However, current efforts are largely focused on disparate and often irreproducible experimental systems. Here we present the results of a one-and-a-half-day workshop that

Report from the Winter Mid-Atlantic Microbiome Meet-up on Biodefense and Pathogen Detection, College Park, MD January 10th, 2018

November 5, 2018
Author(s)
Jacquelyn S. Meisel, Daniel Nasko, Brian Brubach, Victoria Cepeda Espinoza, Jessica Chopyk, Hector Corrada Bravo, Marcus Fedarko, Jay Ghurye, Kiran Javkar, Nathan D. Olson, Nidhi Shah, Sarah M. Allard, Adam L. Bazinet, Nichloas H. Bergman, Alexis Brown, Greg Caporaso, Sean Conlan, Jocelyn DiRuggiero, Samuel Forry, Nur A. Hasan, John Julias, Paul M. Luethy, Donald K. Milton, Brian Ondov, Sarah Preheim, Tara O'Toole, Stephanie Rogers, M.J. Rosovitz, Eric G. Sakowski, Nils O. Schliebs, Daniel D. Sommer, Krista Ternus, German Uritskiy, Sean X. Zhang, Mihai Pop, Todd Treangen
The Mid-Atlantic Microbiome Meet-up (M3) organization held its fourth meeting on January 10, 2018 in College Park, Maryland. M3 brings together academic, government, and industry groups in the broadly-defined mid-Atlantic region to share ideas and develop
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