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Carl Simon Jr., Anne L. Plant, Catherine Zander, Erich Bozenhardt, Christina Celluzzi, David Dobnik, Melanie Grant, John Hughes, Uma Lakshmipathy, Kok-Seong Lim, Laura Montgomery, Hesham Nawar, Thiana Nebel, Linda Peltier, James Sherley, Rouzbeh Taghizadeh, Eddie Tan, Sandrine Vessillier
One of the most challenging aspects of cell and gene therapy products (CGTPs) is defining mechanism of action (MOA), potency and efficacy of the product. This perspective examines these concepts and presents helpful ways to think about them through the
Katrice Lippa, Jan Konijnenburg, Loren Minnich, Tanvi Pandya, James Willis
Every day, overweight and excessively heavy vehicles cause damage to roads, bridges, and other vehicle-based infrastructure. To protect this vital transportation infrastructure for the U.S., states have imposed weight limits for commercial and fleet
John McGuire, David Sefcik, Lisa Warfield, Yvonne Branden, Katrice Lippa
NIST Handbook 130 includes a compilation of model laws and regulations and related interpretations and guidelines designed to encourage uniformity in adoption and implementation of weights and measures laws and regulations. The model laws and regulations
In FY 2022, the 22 federal agencies that reported did not add or rescind any GUS in lieu of VCS, leaving a total of 80 previously reported GUS in lieu of VCS still in use. This analysis does not reflect the use of standards by the Department of Defense
In digital forensics, file system analysis is a precursor task to event reconstruction. Often, unallocated content within a file system is content of interest to an investigation, and thus recognition, extraction, and ascription of unallocated files are
Alexander Kuan, Kareem Aggour, Shengyen Li, Yan Lu, Luke Mohr, Alex Kitt, Hunter Macdonald
Additive manufacturing (AM) leverages emerging technologies and well-adopted processes to produce near-net-shape products. The advancement of AM technology requires data management tools to collect, store and share information through the product
Darwin Reyes-Hernandez, Mandy Esch, Lorna Ewart, Rohollah Nasiri, Anna Herland, Carolina Lucchesi, Kyung Sung, MONICA PIERGIOVANNI, Jelena Vukasinovic, James Shoemaker, Nureddin Ashammakhi
Limitations with cell cultures and experimental animal-based studies have had the scientific and industrial communities searching for new approaches that can provide reliable human models for applications such as drug development, toxicological assessment
Apparent negative crack growth is often encountered when performing elastic-plastic fracture toughness tests with the Elastic Compliance single-specimen technique. It consists of a decrease of specimen compliance (reduction of crack size) during the early
Marla L. Dowell, Hannah Brown, Gretchen Greene, Paul D. Hale, Brian Hoskins, Sarah Hughes, Bob R. Keller, R Joseph Kline, June W. Lau, Jeff Shainline
The CHIPS and Science Act of 2022 called for NIST to "carry out a microelectronics research program to enable advances and breakthroughs....that will accelerate the underlying R&D for metrology of next-generation microelectronics and ensure the
Thomas W. Vetter, Colleen E. Bryan Sallee, Brian Lang, Anthony F. Marlow, Jennifer Ness, Rick L. Paul, Adam L. Pintar, Bruce Scruggs, Nicholas Sharp, Maria Isabel Vega Martinez, John Sieber
Standard Reference Material (SRM) 2693a Bituminous Coal (Nominal Mass Fraction 0.5 % Sulfur) is intended for use in the evaluation of techniques employed in the determination of sulfur, mercury, chlorine, and ash in coal and materials of a similar matrix
We present the long-term timing accuracy of STL receivers by validating their performance against UTC(NIST), the timing reference at the National Institute of Standards and Technology (NIST), for a duration of 100 days. STL is a mature timing and location
Standard Reference Materia® (SRM®) 2246a Relative Intensity Correction Standard for Raman Spectroscopy: 830 nm Excitation is intended for use in the correction of the relative intensity of Raman spectra obtained with Raman instruments employing 830 nm
Eleftheria Ntonti, Sofia Sotiriadou, Marc Assael, Marcia L. Huber, Boris Wilthan, Manabu Watanabe
The available experimental data for the density, thermal conductivity, and viscosity of liquid titanium, zirconium, hafnium, vanadium, niobium, tantalum, chromium, molybdenum, and tungsten have been critically examined with the intention of establishing
To advance the additive manufacturing (AM) technologies, R&D projects may evaluate new facilities and different processes that need a scalable data architecture to accommodate the progressing knowledge. This work introduces a data pedigree to enable the
As interest in digital engineering within a variety of technical domains begins to accelerate, certain industries continue to encounter obstacles with regards to implementing—and benefiting from—digital twin technologies. One of the key challenges facing
Hakju Oh, Boonserm Kulvatunyou, Albert T. Jones, Tim Finin
Today, businesses rely on numerous information systems to achieve their production goals and improve their global competitiveness. Semantically integrating those systems is essential for businesses to achieve both. To do so, businesses must rely on
This report of the Semiconductors and Microelectronics Working Group of the Interagency Committee on Standards Policy (ICSP) provides an overview of Federal government semiconductors and microelectronics standards activities and recommends standards focus
Elena Jelisic, Nenad Ivezic, Boonserm Kulvatunyou, Perawit Charoenwut, Ana Nikolov
The COVID-19 pandemic has brought the cold chain for bio-pharmaceutical products to the spotlight. To preserve their structure and function, biopharmaceuticals such as cells, proteins and enzymes, RNA molecules, and RNA-based drugs (e.g., mRNA-based COVID
A fundamental equation of state expressed explicitly in the Helmholtz energy is presented for R-1224yd(Z), an environmentally friendly refrigerant for centrifugal chillers, high-temperature heat pumps, and organic Rankine cycles. The equation of state is
Over the past 20 years optical frequency combs, with atomic clocks, have been a powerful and enabling technology in the context of time and frequency measurement. Impressively, optical atomic clocks have yielded an 8 order of magnitude improvement in
This paper critically examines existing ductile crack growth (DCG) corrections for J integral values calculated with the multi-specimen and elastic compliance approaches, as well as two novel/alternative DCG corrections. The benchmark is represented by the
Veruska Malave, Kavita Jeerage, Edward Garboczi, Tara Lovestead
Human studies provide valuable information on components or analytes recovered from exhaled breath, but there are limitations due to inter-individual and intra-individual variation. Future development and implementation of breath tests based on aerosol
Felix Fiedler, Joel Karog, Eric W. Lemmon, Monika Thol
An empirical equation of state in terms of the Helmholtz energy for tetrahydro- furan is presented. In the validity range from the triple-point temperature up to 550 K and pressures up to 600 MPa, the equation of state enables the calculation of all
After a five-year renovation of the National Institute of Standards and Technology (NIST) Boulder, CO, antenna measurement facility, the Antenna On-Axis Gain and Polarization Measurements Service SKU63100S was reinstated with the Bureau International des