U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Bioscience

Cell measurements

Search Publications

Search Title, Abstract, Conference, Citation, Keyword or Author
  • Published Date
Displaying 101 - 125 of 140

Innovative Approaches to Combat Healthcare-Associated Infections Using Efficacy Standards Developed Through Industry and Federal Collaboration

October 5, 2018
Author(s)
Dianne L. Poster, Carl C. Miller, Yaw S. Obeng, Michael T. Postek, Troy E. Cowan, Richard A. Martinello
Nation-wide, healthcare-associated infections (HAIs) infect one in every 25 hospital patients, account for more than 100,000 deaths and increase medical costs by around $96-147B, each year. Ultraviolet-C (UV-C) antimicrobial devices are shown to reduce the

Platform development for expression and purification of stable isotope labeled monoclonal antibodies in Escherichia coli

October 1, 2018
Author(s)
Robert Brinson, James T. Hoopes, Colleen McClung, Na Ke, Lila Kashi, Mehmet Berkmen, Zvi Kelman, Prasad T. Reddy
Proteins labeled with stable isotopes play an important role in structural and biophysical studies including nuclear magnetic resonance, small angle neutron scattering, neutron reflectometry, quantitative mass spec and more. The most common and cost

Evidence for cortisol-cortisone metabolism by marine mammal blubber

June 21, 2018
Author(s)
Thomas M. Galligan, Lori Schwacke, Wayne E. McFee, Ashley Russell
Blubber, a specialized form of adipose tissue in marine mammals, has been identified as a useful matrix for the assessment of steroid hormone homeostasis in cetaceans. However, blubber cortisol measurements are not quantitatively predictive of circulating

C3a receptor antagonism as a novel therapeutic target for chronic rhinosinusitis

June 15, 2018
Author(s)
Jennifer K. Mulligan, Tucker Williamson, Nicholas Reaves, William Carroll, Sarah Stephenson, Peng Gao, Richard R. Drake, Ben Neely, Rodney J. Schlosser, Carl Atkinson
Background: Innate immune factors, including the complement system, have been implicated in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). Here we examine complement activity within the respiratory mucosa of CRSwNP patients, and a

Imaging linear and circular polarization features in leaves with complete Mueller matrix polarimetry

June 1, 2018
Author(s)
C.H. L. Patty, David Luo, Frans Snik, Freek Ariese, Wybren J. Buma, Inge L. ten Kate, Rob J. van Spanning, William Sparks, Thomas Germer, Gy?z? Garab, Michael W. Kudenov
Spectropolarimetry of intact plant leaves allows to probe the molecular architecture of vegetation photosynthesis in a non-invasive and non-destructive way and, as such, can offer a wealth of physiological information. In addition to the molecular signals

Opportunities and Challenges in Implementation of Multiparameter Single Cell Analysis Platforms for Clinical Translation

May 11, 2018
Author(s)
susan M. Keating, D. Lansing Taylor, Anne L. Plant, E. David Litwack, Peter Kuhn, Emily J. Greenspan, Christopher M. Hartshorn, Caroline C. Sigman, Gary J. Kelloff, Gregory Friberg, Jerry S. Lee, Keisuke Kuida
The high-content interrogation of single cells with platforms optimized for the multiparameter characterization of cells in liquid and solid biopsy samples can enable characterization of heterogeneous populations of cells ex vivo. Doing so will advance the

Do archaea need an origin of replication?

March 1, 2018
Author(s)
Lori Kelman, Zvi Kelman
Chromosomal DNA replication starts at a specific sequence called an origin of replication. Until recently, all archaeal organisms were thought to require origins to replicate their chromosomes. It was recently discovered that some species do not utilize

Large Field of View Quantitative Phase Imaging of Induced Pluripotent Stem Cells and Optical Pathlength Reference Materials

February 23, 2018
Author(s)
Edward J. Kwee, Alexander W. Peterson, Jeffrey R. Stinson, Michael W. Halter, Liya Yu, Michael P. Majurski, Joe Chalfoun, Peter Bajcsy, John T. Elliott
Induced pluripotent stem cells (iPSCs) are reprogrammed cells that can have heterogeneous biological potential. Quality assurance metrics of reprogrammed iPSCs will be critical to ensure reliable use in cell therapies and personalized diagnostic tests. We

Web Microanalysis of Big Image Data

February 1, 2018
Author(s)
Peter Bajcsy, Joe Chalfoun, Mylene H. Simon
This book looks at the increasing interest in running microscopy processing algorithms on big image data by presenting the theoretical and architectural underpinnings of a web image processing pipeline (WIPP). Software-based methods and infrastructure

Controlled Potential Electrooxidation of Genomic DNA

January 11, 2018
Author(s)
Vytautas Reipa, Donald H. Atha, Sanem Hosbas Coskun, Christopher M. Sims, Bryant C. Nelson
Exposure of mammalian cells to oxidative stress can result in DNA damage that adversely affects many cell processes. We used bulk electrolysis in an electrochemical system and gas chromatographic mass spectrometric analysis (GC/MS/MS) to control and

Modeling, Validation and Verification of Three-Dimensional Cell-Scaffold Contacts from Terabyte- sized Images

December 1, 2017
Author(s)
Peter Bajcsy, Sowon Joy Yoon, Stephen Florczyk, Nathan Hotaling, Mylene H. Simon, Piotr Szczypinski, Nicholas J. Schaub, Carl G. Simon Jr., Mary C. Brady, Ram D. Sriram
Background: Cell-scaffold contact measurements are derived from pairs of co-registered volumetric fluorescent confocal laser scanning microscopy (CLSM) images (z-stacks) of stained cells and spun coat, large microfiber, and medium microfiber scaffolds. Our
Was this page helpful?