NOTICE: Due to a lapse in annual appropriations, most of this website is not being updated. Learn more.
Form submissions will still be accepted but will not receive responses at this time. Sections of this site for programs using non-appropriated funds (such as NVLAP) or those that are excepted from the shutdown (such as CHIPS and NVD) will continue to be updated.
An official website of the United States government
Here’s how you know
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
Chromosomal DNA replication starts at a specific sequence called an origin of replication. Until recently, all archaeal organisms were thought to require origins to replicate their chromosomes. It was recently discovered that some species do not utilize origins of replication under laboratory growth conditions.
Kelman, L.
and Kelman, Z.
(2018),
Do archaea need an origin of replication?, Trends in Microbiology, [online], https://doi.org/10.1016/j.tim.2017.12.001
(Accessed October 10, 2025)