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Bioscience

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Displaying 1 - 25 of 1280

Photopolymer Additive Manufacturing 2025 Workshop Report: Building a Unified Vision from Research to Regulation

June 10, 2026
Author(s)
Callie Higgins, Jason Killgore, Mike Idacavage, Vince Anewenter, Mickey Fortune, Gary Cohen, Perri Katzman, Jessica Hemond, Spencer Loveless, Michael Gould
The third biannual Photopolymer Additive Manufacturing Alliance Workshop was held on September 15-16, 2025, at the University of Colorado Boulder to continue its mission of advancing photopolymer additive manufacturing (PAM). Building on the 2023 PAMA

Procedural Rigor and Reproducibility in NMR Metabolomics: Community Practices and Challenges

May 22, 2026
Author(s)
Tracey Johnston, Leo Cheng, Anastasios Theodorou, Marie Phelan, Goncalo J Gouveia, Robert Powers, Panteleimon Takis, Fabio Casu, Robert Brua, Gagandeep Kaur, Wimal Pathmasiri, Teklab Gebregiworgis, Valerie Copie
Nuclear magnetic resonance (NMR) spectroscopy is a fundamental tool of metabolomics, valued for its reproducibility, quantitative accuracy, and broad applicability across biological and clinical sciences. However, despite its strengths, methodological

Development, characterization, and inter-laboratory validation of methylated human cell free DNA candidate reference materials

May 18, 2026
Author(s)
Zhiyong He, Hua-Jun He, Kenneth Cole, Yves Konigshofer, Russell Garlick, Jayanthi Ramprakash, Matthew Young, Eric Hall, Adam Corner, Michelle Clarissa, Jocelyn Wright, Victoria Cannon, Ming Yu, William Grady, Cecilia Yeung, Zachary Heimer, Zhili Wang, ShiPing Zou, Shidong Jia, Fang Liu, Giancarlo Bonora, Karol Bomsztyk, Daniel Mar
Aberrant DNA methylation biomarkers have demonstrated potential for early cancer detection, multicancer detection, and determining the tissue of origin. Due to their stability, frequency, and accessibility in bodily fluids, circulating cell-free DNA (cfDNA

Beyond Sequence Similarity: The Case for Function-Based Screening of Nucleic Acid Synthesis

May 13, 2026
Author(s)
Gary Able, Tessa Alexanian, Jacob Beal, James Diggans, Kevin Flyangolts, Gene D. Godbold, Eric Horvitz, Bin Hu, Caitlin Jagla, Rassin Lababidi, Brittany Rife Magalis, Sebastian Rivera, Bruce Wittmann, Samuel Forry, David Ross, Sheng Lin-Gibson, Samuel Curtis
Synthetic nucleic acids are a key input to modern biotechnology, yet they represent dual-use materials that require robust screening to mitigate biosecurity risks. The prevailing screening paradigm identifies sequences of concern (SoCs) through sequence

The Integration of Focused Ultrasonication, ddPCR, and Flow Cytometry Effectively Estimates Genome Copies per Cell and Enhances DNA Extraction Efficiency in Escherichia coli Samples

April 16, 2026
Author(s)
Sandra Da Silva, Nancy Lin, Kirsten Parratt, Hariharan Iyer, Guilherme Pinheiro, Holly Hack, Ian Hines, Stephanie Servetas
Microbiology researchers rely on nucleic acid measurement techniques, such as the quantitative polymerase chain reaction (qPCR) and DNA sequencing, to address diverse scientific and practical challenges. These applications range from detecting microbial

Serum proteome of the Egyptian rousette bat (Rousettus aegyptiacus) reveals signatures of immunity, proteostasis, and metabolism

April 6, 2026
Author(s)
Brooke Genovese, Nistara Randhawa, Benjamin Neely, Gabriela Grigorean, Amy Schuh, Brian Amman, Jessica Elbert, Simon Anthony, Jonna Mazet, Jonathan Towner, Brian Bird
Bats are increasingly studied for their ability to coexist with diverse viruses of human health importance. While this focus has yielded insights into host–pathogen dynamics, baseline physiological data from healthy bats remain limited, constraining

Advancing evanescent light scattering microscopy for single-particle characterization of gene delivery nanoparticles

March 4, 2026
Author(s)
Jagat Budhathoki, Gregory Cooksey, Matthew DiSalvo, Thomas Germer, Peter Bajcsy, Edward Kwee, Aaron Goldfain, Alexander Peterson
Precise and reproducible single-nanoparticle characterization is essential for advancing gene therapy, where viral vectors encapsulating therapeutic genes must be evaluated under formulation-relevant conditions. We present a label-free optical platform

Demonstration, validation, and application of hyperspectral microscopy for the collection of cyanobacterial spectral signatures

February 24, 2026
Author(s)
Natalie C. Hall, Adam Mumford, Aaron Goldfain, David Allen, Terry slonecker, Alisa Shtabnoy
Cyanobacterial and other algal blooms are an environmental concern in waterbodies worldwide. While these blooms are a nuisance for recreational activities, they can also be harmful to human and wildlife health when the algae produce and release toxins

The National Marine Mammal Tissue Bank Specimen Inventory Report

January 29, 2026
Author(s)
Jennifer Ness, Debra Ellisor, Jennifer Hoguet, Amanda Moors, Amanda Capuano, Rebecca Pugh
This report provides a brief background of the National Marine Mammal Tissue Bank (NMMTB), information on the composition of the collection, policies for specimen use, and links to a downloadable and searchable specimen inventory. The inventory covers

AI driven 3D subcellular RPE map discovers cell state transitions in establishment of apical-basal polarity

January 12, 2026
Author(s)
Davide Ortolan, Pushkar Sathe, Andrei Volkov, Dominik Reichert, Sheldon Sebastian, Arvydas Maminishkis, Nicolas Schaub, Devika Bose, Jorge Alejandro Suarez de Freitas Ferrari, Nyusha Lin, Gianluca Pegoraro, Carl Simon, Ruchi Sharma, Peter Bajcsy, Kapil Bharti
The retinal pigment epithelium (RPE) is a specialized cell monolayer that forms the barrier between the subretinal and choroidal spaces. During development, RPE cells polarize perpendicular to the monolayer plane such that organelles attain specific

A mathematical framework to correct for compositionality in microbiome datasets

January 6, 2026
Author(s)
Samuel Forry, Stephanie Servetas, Jason Kralj, Monique Hunter, Jennifer Dootz
The increasing use of metagenomic sequencing (MGS) for microbiome analysis has significantly advanced our understanding of microbial communities and their roles in various biological processes, including human health, environmental cycling, and disease

Intermethod Characterization of Commercially Available Extracellular Vesicles as Reference Materials

December 30, 2025
Author(s)
Sumeet Poudel, Diane Nelson, Blaza Toman, Zhiyong He, Ashley Green, Thomas Cleveland, Sean Lehman, Wyatt Vreeland, Kurt Benkstein, Bryant Nelson, Lili Wang, Elzafir Elsheikh, Yuefan Wang, Hui Zhang
The National Institute of Standards and Technology (NIST) is developing analytical methods to characterize extracellular vesicles (EVs) to support the urgent need for standardized EV reference materials (RMs). This study used orthogonal techniques

The Need for Standardization of Extracellular Vesicle Characterization Methods

October 1, 2025
Author(s)
Bryant Nelson, Wyatt Vreeland
Extracellular vesicles (EVs) are secreted from all living organisms. The application of EVs in therapeutics, clinical diagnostics and drug delivery is expanding rapidly and the EV field is set to capitalize on this expansion through the development of next

NIST 2025 Rapid Microbial Testing Methods Workshop Report

September 26, 2025
Author(s)
Jason Kralj, Kirsten Parratt, Tyler Laird, Stephanie Servetas, Nancy Lin, Dawn Henke, Scott Jackson
In 2020, the National Institute of Standards and Technology (NIST)-led Rapid Microbial Testing Methods (RMTM) Consortium was established to develop standards and measurement-based solutions to facilitate the adoption of RMTMs in advanced therapy products

Report from the 2023 NIST-Hosted Workshop on Collaborative Efforts to Enable Adoption of Rapid Microbial Testing Methods for Advanced Therapy Products

September 26, 2025
Author(s)
Stephanie Servetas, Dawn Henke, Jason Kralj, Kirsten Parratt, Scott Jackson, Nancy Lin
On April 25, 2023, the National Institute of Standards and Technology (NIST) hosted a one-day hybrid workshop focused on bringing together organizations and working groups with the common goal of enabling validation and implementation of rapid microbial

NIST 2024 Rapid Microbial Testing Methods Workshop Report

September 25, 2025
Author(s)
Jason Kralj, Nancy Lin, Kirsten Parratt, Stephanie Servetas, Dawn Henke, Scott Jackson
The NIST-led Rapid Microbial Testing Methods (RMTM) Consortium launched in 2020 to develop standards and measurement-based solutions to advance the use of RMTMs in advanced therapy products. NIST hosted 4th annual workshop on RMTMs to update the community
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