NOTICE: Due to a lapse in annual appropriations, most of this website is not being updated. Learn more.
Form submissions will still be accepted but will not receive responses at this time. Sections of this site for programs using non-appropriated funds (such as NVLAP) or those that are excepted from the shutdown (such as CHIPS and NVD) will continue to be updated.
An official website of the United States government
Here’s how you know
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
Predicted Functions of MdmX in Fine Tuning the Response of p53 to DNA Damage
Published
Author(s)
Sohyoung Kim, Mirit I. Aladjem, Geoffrey B. McFadden, Kurt W. Kohn
Abstract
Tumor suppressor protein p53 is negatively regulated by two structurally homologous proteins, Mdm2 and MdmX. In contrast to Mdm2, MdmX lacks ubiquitin ligase activity. Although the essential interactions of MdmX are known, it is not clear how they function to regulate p53. We investigated interaction models consisting of p53, Mdm2 and MdmX. Our simulations show that MdmX could amplify and stabilize DNA damage-induced p53 responses. These effects of MdmX involve a reservoir-based mechanism with simple competitive interactions. The amplification effect of MdmX induced switch-like p53 responses early after DNA damage. Late in the DNA damage response, MdmX dampened oscillations, suggesting that MdmX could suppress p53 activity when p53 activity is subject to progressive rise due to the feedback between p53 and Mdm2.
Kim, S.
, Aladjem, M.
, McFadden, G.
and Kohn, K.
(2010),
Predicted Functions of MdmX in Fine Tuning the Response of p53 to DNA Damage, PLOS Computational Biology, [online], https://doi.org/10.1371/journal.pcbi.1000665
(Accessed October 11, 2025)