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The next dimension in STR sequencing: Polymorphisms in flanking regions and their allelic associations

Published

Author(s)

Katherine Gettings, Rachel A. Aponte, Kevin M. Kiesler, Peter Vallone

Abstract

Sequence data was analyzed from the flanking and repeat regions of 22 autosomal STR loci in 183 population samples. The flanking regions of the loci sequenced in this data set can be divided into six categories, based on the types of polymorphisms they contain: 1) multiple polymorphisms in haplotype, 2) "old" single polymorphisms, 3) population or allele specific polymorphisms, 4) polymorphisms associated with sequence variants, 5) rare polymorphisms, and 6) no polymorphisms. These results provide an indication of which loci are expected to gain in areas such as allelic diversity and ancestry information by including flanking regions in STR sequence analysis.
Citation
Forensic Science International: Genetics Supplement Series

Keywords

STR loci, SNP, next generation sequencing

Citation

Gettings, K. , Aponte, R. , Kiesler, K. and Vallone, P. (2015), The next dimension in STR sequencing: Polymorphisms in flanking regions and their allelic associations, Forensic Science International: Genetics Supplement Series, [online], https://doi.org/10.1016/j.fsigss.2015.09.049 (Accessed November 28, 2021)
Created September 23, 2015, Updated November 10, 2018