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Metabolomics 2022 Workshop Report: State of QA/QC Best Practices in LC-MS-Based Untargeted Metabolomics, Informed Through mQACC Community Engagement Initiatives

Published

Author(s)

Tracey Schock, Warwick Dunn, Julia Kuligowski, Jonathan Mosley, Candice Ulmer Holland, Dajana Vuckovic

Abstract

Introduction: The Metabolomics Quality Assurance and Quality Control Consortium (mQACC) organized a workshop during the Metabolomics 2022 conference. Objectives: The goal of the workshop was to disseminate recent findings from mQACC community-engagement efforts and to solicit feedback about a "living guidance" document of QA/QC best practices for untargeted LC-MS metabolomics. Methods: The workshop focused on four QC-related topics, with a short presentation on each topic followed by audience poll and open discussion. Results: Participants expressed the need for detailed guidance on a broad range of QA/QC-related topics accompanied by use-cases. Conclusion: Ongoing efforts will continue to identify, catalog, harmonize, and disseminate QA/QC best practices, including outreach activities, to establish and continually update QA/QC guidelines.
Citation
Metabolomics

Keywords

metabolomics, quality control (QC) samples, Liquid Chromatography – Mass Spectrometry (LC-MS), internal standards, blanks, system suitability testing (SST), analytical batch

Citation

Schock, T. , Dunn, W. , Kuligowski, J. , Mosley, J. , Ulmer Holland, C. and Vuckovic, D. (2023), Metabolomics 2022 Workshop Report: State of QA/QC Best Practices in LC-MS-Based Untargeted Metabolomics, Informed Through mQACC Community Engagement Initiatives, Metabolomics, [online], https://doi.org/10.1007/s11306-023-02060-4, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=936459 (Accessed March 2, 2024)
Created November 8, 2023, Updated December 6, 2023