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Measuring the Hydrodynamic Size of Nanoparticles in Aqueous Media Using Batch-Mode Dynamic Light Scattering

Published

Author(s)

Vincent A. Hackley, Jeffrey D. Clogston

Abstract

Particle size characterization is of particular importance to nanomedicine as “nano” is a dimensional definition, and the size similarity of nanoparticles to biological moieties is believed to impart many of their unique medical properties. Here we present a method for sample preparation and the determination of mean nanoparticle size (hydrodynamic diameter) using batch-mode dynamic light scattering (DLS) in dilute aqueous suspensions. We then demonstrate this method for 30 nm colloidal gold.
Citation
Characterization of Nanoparticles Intended for Clinical Applications
Publisher Info
Humana Press, Totowa, NJ

Keywords

Hydrodynamic size, dynamic light scattering, photon correlation spectroscopy, quasi-elastic light scattering, DLS, PCS, QELS, diffusion, diffusion coefficient, particle size

Citation

Hackley, V. and Clogston, J. (2011), Measuring the Hydrodynamic Size of Nanoparticles in Aqueous Media Using Batch-Mode Dynamic Light Scattering, Humana Press, Totowa, NJ (Accessed April 14, 2024)
Created January 1, 2011, Updated February 19, 2017