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Mass spectrometry quantification of clusterin in the human brain



Junjun J. Chen, Meiyao M. Wang, Illarion V. Turko


A multifunctional glycoprotein clusterin has been associated with late-onset Alzheimer’s disease (AD). This finding should prompt further investigation to define the role of clusterin in AD phenotypes. For that reason, the development of techniques to quantify level, potential post-translational modifications, and isoforms of clusterin would be important. We have developed a quantitative technique based on multiple reaction monitoring mass spectrometry to measure clusterin in the human postmortem brain tissues.
Molecular Neurodegeneration


multiple reaction monitoring, mass spectrometry, isotope-labeled standard, quantification, Alzheimer's disease


Chen, J. , Wang, M. and Turko, I. (2012), Mass spectrometry quantification of clusterin in the human brain, Molecular Neurodegeneration, [online], (Accessed May 28, 2024)


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Created August 20, 2012, Updated November 10, 2018