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MAGF: A New Method for High-performance Focusing of Uncharged and Hydrophobic Analytes

Published

Author(s)

David J. Ross, K M. Balss, P B. Howell, Wyatt N. Vreeland

Abstract

A new method for analyte focusing is demonstrated that can be used for concentration and separation of analytes based upon their affinity for a micellar phase. The method works by producing (through the application of a temperature gradient) a gradient in the retention factor of a hydrophobic analyte into a micellar phase. This new method, which we call micellar affinity gradient focusing (MAGF), is the first microfluidic method that can be used for focusing and separation based upon analyte properties other than electrophoretic properties. It combines the affinity-based separation of micellar electrokinetic chromatography (MEKC) with the advantages inherent to focusing methods.
Proceedings Title
7th International Conference on Miniaturized Chemical and Biochemical Analysis Systems
Conference Dates
October 5-9, 2003
Conference Location
Squaw Valley, CA

Keywords

focusing, MEKC, neutral analysis, separations

Citation

Ross, D. , Balss, K. , Howell, P. and Vreeland, W. (2003), MAGF: A New Method for High-performance Focusing of Uncharged and Hydrophobic Analytes, 7th International Conference on Miniaturized Chemical and Biochemical Analysis Systems, Squaw Valley, CA (Accessed August 18, 2022)
Created October 1, 2003, Updated February 19, 2017