Inhibition of cellular proliferation and enhancement of hydrogen peroxide production in fibrosarcoma cell line by weak radio frequency magnetic fields

Published

September 23, 2014

Author(s)

Pablo Castello, Iain Hill, Lucas Portelli, Frank Barnes, Robert J. Usselman, Carlos Martino

Abstract

This study presents experimental data for the effects of weak radio frequency (RF) magnetic fields on hydrogen peroxide (H2O2) production and cellular growth rates of fibrosarcoma HT1080 cells in vitro. Cells were exposed either to 45mT static magnetic fields (SMFs)-oriented vertical to the plane of growth or to SMFs combined with weak 5 and 10MHz RF magnetic fields of 10mTRMS intensity perpendicular to the static field. Cell numbers were reduced up to 30% on Day 2 for the cells exposed to the combination of SMF and a 10MHz RF magnetic field compared with the SMF control cells. In addition, cells exposed to 10MHz RF magnetic fields for 8 h increased H2O2 production by 55%. The results demonstrate an overall magnetic field-induced biological effect that shows elevated H2O2 levels with accompanying decrease in cellular growth rates.

Citation

Bioelectromagnetics

Volume

35

Issue

8

Pub Type

Journals

Download Paper

https://doi.org/10.1002/bem.21858

Local Download

Keywords

radio frequency, magnetic field effects, cellular growth curves, cancer cells, hydrogen peroxide, radical pair mechanism

Citation

Castello, P. , Hill, I. , Portelli, L. , Barnes, F. , Usselman, R. and Martino, C. (2014), Inhibition of cellular proliferation and enhancement of hydrogen peroxide production in fibrosarcoma cell line by weak radio frequency magnetic fields, Bioelectromagnetics, [online], https://doi.org/10.1002/bem.21858, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=914946 (Accessed October 11, 2024)