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Fast quantification of nanorod geometry by DMA-spICP-MS



Jiaojie Tan, Yong Yang, Hind El Hadri, Mingdong M. Li, Vincent A. Hackley, Michael R. Zachariah


A fast, quantitative method for determining the geometries of nanorods (i.e., length and dimeter) is described, based on hyphenation of differential mobility analysis (DMA) with single particle inductively coupled plasma mass spectrometry (spICP-MS). Seven gold nanorod samples with different dimensions (diameters 11.8-38.2 nm, aspect ratios 1.8-6.9) were used to validate the method. We demonstrate that DMA-spICP-MS can (1) achieve quantification of both length and diameter comparable with TEM analysis, (2) make statistically meaningful measurements in minutes at low concentrations and (3) separate nanorods from spheres and quantify the geometry of each population. A robustness analysis of this method was performed to evaluate potential biases in this approach.


ion mobility analysis, gold nanorod, high aspect particles, dimensional metrology, single particle ICP-MS
Created February 18, 2019, Updated March 25, 2019