An Experimental Method for Measuring Mechanical Properties of Rat Pulmonary Arteries Verified With Latex

Published

June 1, 2003

Author(s)

Elizabeth S. Drexler, Andrew J. Slifka, J Wright, Christopher N. McCowan, Dudley Finch, Timothy P. Quinn, J D. McCloskey, Dunbar Ivy, Robin Shandas

Abstract

A study of the biomechanics and hemodynamics of pulmonary hypertension is incomplete without including mechanical properties data comparing healthy and diseased arterial tissue. In the initial stabe of this study, Sprague-Dawley rats will be induced with pulmonary hypertension through hyposia or injection of monocrotaline. Testing these small, nonlinear samples pose a challenge for developing a test method that will generate quality, reproducible data in the pressure range experienced by the hypertensive pulmonary artery. This paper describes such a test method, where the control of the experimental inputs is of the precision to yield an experimental error of {difference} 4 %. The method is calibrated against 75 m thick latex and the data are in good agreement with the Neo-Hookian model.

Citation

Journal of Research (NIST JRES) -

Volume

108 No. 3

NIST Pub Series

Journal of Research (NIST JRES)

Pub Type

NIST Pubs

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Keywords

apparatus, biaxial test, latex, mechanical properties, nonlinear material, pulmonary hypertension, rat pulmonary artery

Citation

Drexler, E. , Slifka, A. , Wright, J. , McCowan, C. , Finch, D. , Quinn, T. , McCloskey, J. , Ivy, D. and Shandas, R. (2003), An Experimental Method for Measuring Mechanical Properties of Rat Pulmonary Arteries Verified With Latex, Journal of Research (NIST JRES), National Institute of Standards and Technology, Gaithersburg, MD, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=851318 (Accessed October 15, 2025)