There is growing recognition that cells can sense and respond to the physical cues from their environment, such as stiffness, mechanical loading and topology. Physical properties of the matrix can direct cellular response and are critical in the design of scaffolds for tissue engineering. In this work we examined the effect of matrix modulus on differentiation of human bone marrow stromal cells (hBMSCs) encapsulated within three-dimensional (3D) photo-polymerizable polyethylene glycol (PEG) hydrogels. Further, to investigate the topological effects of the hydrogel scaffolds on cellular differentiation we studied the response of hBMSCs on the gel surface (2D) and those encapsulated within the hydrogel (3D).
Proceedings Title: American Chemical Society
Conference Dates: August 22-26, 2010
Conference Location: boston, MA
Pub Type: Conferences
hydrogel, scaffold, tissue engineering, stem cell