Entropophoresis motion caused by an entropy gradient is a novel nanofluidic method to direct the self-transport of biopolymers that established a new paradigm of nanofluidic functionality with broad relevance to lab-on-a-chip technol-ogy. Here, the entropic effects on size variation of DNA molecules descending a nanofluidic staircase by entropophoresis are studied. A simple numerical model provides insight into the behavior of confined biopolymers a controversial topic of basic importance in many lab-on-a-chip applications and informs the rational design and self-operation of nanofluidic devices for future entropophoretic applications, such as the directed self-separation of biomolecular mixtures and directed self-patterning of biomolecular concentration gradients.
Proceedings Title: DNA ENTROPOPHORESIS: A BALANCE OF ENTROPY AND DIFFUSION IN COMPLEX NANOCONFINEMENT
Conference Dates: October 2-6, 2011
Conference Location: Seattle, WA
Conference Title: The 15th International Conference on Miniaturized Systems for Chemistry and Life sciences
Pub Type: Conferences
Nanofluidics, DNA, Entropophoresis, Ideal chain, Polymer