Vaish, A.
, Vanderah, D.
, Richter, L.
, Dimitriou, M.
, Steffens, K.
and Walker, M.
(2015),
Dithiol-based Modification of Poly(dopamine): Enabling Protein Resistance Via Short-Chain Ethylene Oxide Oligomers, Chemical Communications, [online], https://doi.org/10.1039/c5cc00299k
(Accessed October 10, 2025)
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Dithiol-based Modification of Poly(dopamine): Enabling Protein Resistance Via Short-Chain Ethylene Oxide Oligomers
Published
Author(s)
Amit Vaish, , , Michael Dimitriou, ,
Abstract
We present a facile strategy to modify poly(dopamine)(PDA)-coated substrates. Using thiol-terminated short chain ethylene oxide oligomers (OEG) under aqueous conditions, we explore the creation of a model surface exhibiting resistance to nonspecific protein absorption (RPA) by engineering the surface properties of a PDA adlayer. Surprisingly, dithiol-terminated OEG molecules demonstrated significantly greater coverage on PDA surfaces than analogous monothiol molecules. Successful RPA is only achieved with dithiol-terminated OEGs.Citation
Chemical Communications
Volume
51
Pub Type
Journals
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Keywords
ethylene oxide oligormers, PDA, polydopa, poly(dopamine), protein resistance, SAM, self-assembled monolayers, surface functionalization, thin film
Citation
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Created March 15, 2015, Updated October 12, 2021