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Dithiol-based Modification of Poly(dopamine): Enabling Protein Resistance Via Short-Chain Ethylene Oxide Oligomers

Published

Author(s)

Amit Vaish, David J. Vanderah, Lee J. Richter, Michael Dimitriou, Kristen L. Steffens, Marlon L. Walker

Abstract

We present a facile strategy to modify poly(dopamine)(PDA)-coated substrates. Using thiol-terminated short chain ethylene oxide oligomers (OEG) under aqueous conditions, we explore the creation of a model surface exhibiting resistance to nonspecific protein absorption (RPA) by engineering the surface properties of a PDA adlayer. Surprisingly, dithiol-terminated OEG molecules demonstrated significantly greater coverage on PDA surfaces than analogous monothiol molecules. Successful RPA is only achieved with dithiol-terminated OEGs.
Citation
Chemical Communications
Volume
51

Keywords

ethylene oxide oligormers, PDA, polydopa, poly(dopamine), protein resistance, SAM, self-assembled monolayers, surface functionalization, thin film

Citation

Vaish, A. , Vanderah, D. , Richter, L. , Dimitriou, M. , Steffens, K. and Walker, M. (2015), Dithiol-based Modification of Poly(dopamine): Enabling Protein Resistance Via Short-Chain Ethylene Oxide Oligomers, Chemical Communications, [online], https://doi.org/10.1039/c5cc00299k (Accessed April 19, 2024)
Created March 15, 2015, Updated October 12, 2021