Dietary Supplement Laboratory Quality Assurance Program: Exercise 3 Final Report

Published

September 4, 2025

Author(s)

Jenna Klingsick, Hugh Hayes, Elena Wood

Abstract

The National Institute of Standards and Technology (NIST) Dietary Supplement Laboratory Quality Assurance Program (DSQAP) was launched in 2007 as a collaboration with the National Institutes of Health (NIH) Office of Dietary Supplements (ODS). The DSQAP enables laboratories to improve the accuracy of measurements for nutrients, marker compounds, toxic elements, and/or contaminants in dietary supplement raw materials, ingredients, and finished products. Primary program goals include centering the consensus range about the target value and reducing the size of the consensus range. Exercise 3 is the eighteenth DSQAP exercise (previously, designated "A" through "O"). Exercise 3 included with four studies, offering the opportunity for laboratories to assess their in-house techniques on a variety of measurements. Studies included determinations of select toxic elements in kava root and kava extract materials, fat-soluble vitamins in two different multivitamin tablets, water-soluble vitamins in a multivitamin and yohimbe containing solid oral dosage form, and botanical marker compounds in kava root and kava extract. This report summarizes the results, describes observations, and provides technical recommendations for measurement improvements.

Citation

NIST Interagency/Internal Report (NISTIR) - 8585

Report Number

8585

NIST Pub Series

NIST Interagency/Internal Report (NISTIR)

Pub Type

NIST Pubs

Download Paper

https://doi.org/10.6028/NIST.IR.8585

Local Download

Keywords

Botanicals, Consumer Safety, Dietary Supplements, Quality Assurance, Reference Materials.

Citation

Klingsick, J. , Hayes, H. and Wood, E. (2025), Dietary Supplement Laboratory Quality Assurance Program: Exercise 3 Final Report, NIST Interagency/Internal Report (NISTIR), National Institute of Standards and Technology, Gaithersburg, MD, [online], https://doi.org/10.6028/NIST.IR.8585, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=960351 (Accessed September 7, 2025)