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The Detection and Characterization of Ions, DNA and Proteins with Nanometer-Scale Pores

Published

Author(s)

John J. Kasianowicz, Jeffrey C. Lerman, Sarah E. Henrickson, Martin Misakian, Rekha Panchal, Kelly Halverson, Sina Bavari, Tam Nguyen, Rick Gussio, Devanand K. Shenoy, Vincent M. Stanford

Abstract

Protein ion channels are nanometer-scale pores that are central to many biological processes, including the sensing of a wide variety of molecules. They have also demonstrated their potential for use in the sensitive and selective detection of ions, the characterization of polynucleotides, and toxins as well as the screening of a therapeutic agent against a key lethal anthrax protein. Further advances in materials engineering, theory, and signal processing are needed to enable practical applications based on biological or synthetic nanopores.
Citation
Handbook of Biosensors and Biochips
Publisher Info
J. Wiley & Sons, Ltd., West Sussex, UK

Keywords

analyte detection, anthrax, ion channels, nanopores, stochastic sensing

Citation

Kasianowicz, J. , Lerman, J. , Henrickson, S. , Misakian, M. , Panchal, R. , Halverson, K. , Bavari, S. , Nguyen, T. , Gussio, R. , Shenoy, D. and Stanford, V. (2007), The Detection and Characterization of Ions, DNA and Proteins with Nanometer-Scale Pores, J. Wiley & Sons, Ltd., West Sussex, UK (Accessed May 30, 2024)

Issues

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Created November 30, 2007, Updated October 12, 2021